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author：

Chen, M. (Chen, M..) [1] | Jiang, Y. (Jiang, Y..) [2] | Zhang, Y. (Zhang, Y..) [3] | Chen, X. (Chen, X..) [4] | Xie, L. (Xie, L..) [5] | Zeng, T. (Zeng, T..) [7] | Liu, Y. (Liu, Y..) [8] | Liu, H. (Liu, H..) [9] | Wang, M. (Wang, M..) [10] | Zhang, Z. (Zhang, Z..) [12] | He, Y. (He, Y..) [13] | Qin, X. (Qin, X..) [14] | Lu, C. (Lu, C..) [15] | Chen, Q. (Chen, Q..) [16] | Yang, H. (Yang, H..) [17]

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Scopus

Abstract：

Precise　monitoring　of　biomolecular　radiation　damage　is　crucial　for　understanding　X-ray-induced　cell　injury　and　improving　the　accuracy　of　clinical　radiotherapy.　We　present　the　design　and　performance　of　lanthanide-DNA-origami　nanodosimeters　for　directly　visualizing　radiation　damage　at　the　single-particle　level.　Lanthanide　ions　(Tb3+　or　Eu3+)　coordinated　with　DNA　origami　nanosensors　enhance　the　sensitivity　of　X-ray　irradiation.　Atomic　force　microscopy　(AFM)　revealed　morphological　changes　in　Eu3+-sensitized　DNA　origami　upon　X-ray　irradiation,　indicating　damage　caused　by　ionization-generated　electrons　and　free　radicals.　We　further　demonstrated　the　practical　applicability　of　Eu3+-DNA-origami　integrated　chips　in　precisely　monitoring　radiation-mediated　cancer　radiotherapy.　Quantitative　results　showed　consistent　trends　with　flow　cytometry　and　histological　examination　under　comparable　X-ray　irradiation　doses,　providing　an　affordable　and　user-friendly　visualization　tool　for　preclinical　applications.　These　findings　provide　new　insights　into　the　impact　of　heavy　metals　on　radiation-induced　biomolecular　damage　and　pave　the　way　for　future　research　in　developing　nanoscale　radiation　sensors　for　precise　clinical　radiography.　©　2024　American　Chemical　Society.

Keyword：

DNA origami Lanthanide sensitizer Radiation damage Radiotherapy X-ray sensitivity

Community：

  • [ 1 ] [Chen M.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 2 ] [Jiang Y.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 3 ] [Zhang Y.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 4 ] [Chen X.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 5 ] [Xie L.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 6 ] [Xie L.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 7 ] [Zeng T.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 8 ] [Liu Y.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 9 ] [Liu H.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 10 ] [Wang M.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 11 ] [Chen X.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 12 ] [Zhang Z.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 13 ] [He Y.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 14 ] [Qin X.]Strait Institute of Flexible Electronics, Fujian Normal University, Fuzhou, 350117, China
  • [ 15 ] [Lu C.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 16 ] [Chen Q.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
  • [ 17 ] [Yang H.]New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, China

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Source ：

Nano Letters

ISSN： 1530-6984

Year： 2024

Issue： 37

Volume： 24

Page： 11690-11696

9 . 6 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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