The　regeneration　of　bone　tissue　is　a　complex　process　requiring　innovative　biomaterials　with　enhanced　osteogenic　properties　to　facilitate　successful　tissue　engineering.　Herein,　a　3D　bionic　scaffold　comprised　of　covalently　bound　graphene/carbon　nanotube　monoliths　are　present　(3DGp/CNTs)　exhibiting　long-range　ordered　porous　characteristics,　showcasing　promising　attributes　for　bone　tissue　applications.　The　lightweight,　all-carbon　scaffolds　not　only　demonstrate　excellent　mechanical　performance　in　the　hydrated　state　but　also　mimic　the　structural　and　functional　features　of　the　extracellular　matrix,　actively　promoting　cellular　adhesion,　proliferation,　and　differentiation.　Significantly,　the　osteogenic　differentiation　of　dental　pulp　stem　cells　(DPSCs)　is　observed,　as　evidenced　by　the　upregulation　of　RUNX2,　OSX,　BSP,　ALP,　OPN,　and　OCN　expression.　This　notable　outcome　can　be　attributed　to　the　synergistic　effect　of　3DGp/CNTs,　which　create　a　conducive　microenvironment　for　DPSCs　and　promote　osteogenic　differentiation　by　activating　the　BMP　pathway.　This　observation　elucidates　the　mechanism　through　which　3DGp/CNTs　induce　DPSC　mineralization.　The　combination　of　these　advantages,　along　with　its　straightforward　and　cost-effective　preparation　technique,　positions　3DGp/CNTs　as　a　promising　candidate　for　dental　clinical　engineering.　©　2024　Wiley-VCH　GmbH.