The　development　of　green　memorizers　with　distinct　mechanism　is　significant.　In　this　work,　renewable　polyphenol　ellagic　acid　(EA)　and　environmentally　friendly　calcium　were　used　to　construct　a　unique　3D　interpenetrated　bio-metal-organic　framework　(BioMOF),　i.e.　{[Ca2(EA)3(4H2O)]·2H2O}n.　Its　high　chemical　stability　stems　from　the　twofold　interpenetrated　(6,3)　bi-layers　and　versatile　strong　π-π　stacking　interactions.　The　memorizer　FTO/{[Ca2(EA)3(4H2O)]·2H2O}n/Ag　exhibits　good　bipolar　resistive　switching　performance　with　an　ON/OFF　ratio　of　5.40　×　103　and　a　tolerant　temperature　of　300　°C.　In　particular,　the　local　conjugated　EA　ligand　and　strong　π-π　stacking　interactions　in　the　interpenetrated　3D　network　are　responsible　for　a　carrier　trapping/de-trapping　process,　rendering　the　excellent　binary　resistive　switching　performance.　This　work　demonstrates　a　new　way　for　the　construction　of　green　electrons　by　adopting　renewable　natural　products　as　organic　linkers.　©　2024　The　Royal　Society　of　Chemistry.