The　purpose　of　this　paper　is　to　examine　the　effect　of　processing　parameters　and　subsequent　heat　treatments　on　the　microstructures　and　bonding　strengths　of　Ti-6Al-4V/AA1050　laminations　formed　via　a　non-equal　channel　lateral　co-extrusion　process.　The　microstructural　evolution　and　growth　mechanism　in　the　diffusion　layer　were　discussed　further　to　optimize　the　bonding　quality　by　appropriately　adjusting　process　parameters.　Scanning　electron　microscopes　(SEM),　energy　dispersive　spectrometer　(EDS),　and　Xray　diffraction　(XRD)　were　used　to　characterize　interfacial　diffusion　layers.　The　shear　test　was　used　to　determine　the　mechanical　properties　of　the　interfacial　diffusion　layer.　The　experimental　results　indicate　that　it　is　possible　to　co-extrusion　Ti-6Al-4V/AA1050　compound　profiles　using　non-equal　channel　lateral　co-extrusion.　Different　heat　treatment　processes　affect　the　thickness　of　the　diffusion　layer.　When　the　temperature　and　time　of　heat　treatment　increase,　the　thickness　of　the　reaction　layers　increases　dramatically.　Additionally,　the　shear　strength　of　the　Ti-6Al-4V/AA1050　composite　interface　is　proportional　to　the　diffusion　layer　thickness.　It　is　observed　that　a　medium　interface　thickness　results　in　superior　mechanical　performance　when　compared　to　neither　a　greater　nor　a　lesser　interface　thickness.　Microstructural　characterization　of　all　heat　treatments　reveals　that　the　only　intermetallic　compound　observed　in　the　diffusion　layers　is　TiAl3.　Due　to　the　inter-diffusion　of　Ti　and　Al　atoms,　the　TiAl3　layer　grows　primarily　at　AA1050/TiAl3　interfaces.　(c)　2023　China　Ordnance　Society.　Publishing　services　by　Elsevier　B.V.　on　behalf　of　KeAi　Communications　Co.　Ltd.　This　is　an　open　access　article　under　the　CC　BY-NC-ND　license　(http://creativecommons.org/　licenses/by-nc-nd/4.0/).