The　formidable　challenge　of　membrane　fouling　and　wetting,　spurred　by　the　elevated　concentration　of　pollutants　in　the　landfill　leachate　concentrate　during　membrane　distillation,　necessitates　substantial　costs　on　membrane　cleaning　for　retaining　high　separation　efficiency.　Herein,　a　durable　superhydrophobic　poly(vinylidene　fluoride)　(PVDF)　membrane　constructed　by　spray-coating　of　fluorinated　SiO2　nanoparticles　was　proposed　to　treat　landfill　leachate　concentrate　via　membrane　distillation.　The　influence　of　operational　parameters,　including　transmembrane　temperature　difference,　feed　flow　rate,　and　feed　salinity,　on　the　membrane　distillation　performance　was　explored.　Specifically,　the　increased　transmembrane　temperature　difference　and　feed　flow　rate　had　a　strongly　positive　dependence　on　the　permeation　flux　during　membrane　distillation.　The　superhydrophobic　PVDF　membrane　showed　impressive　antiwetting　and　antifouling　properties,　as　indicated　by　consistently　stable　superhydrophobicity,　obtaining　an　extremely　high　rejection　of　salts　and　humic　substances　(＞99.99%)　over　an　8　h　membrane　distillation　for　treating　landfill　leachate　concentrate.　Furthermore,　the　tested　superhydrophobic　PVDF　membrane　yielded　a　complete　solute　removal,　resulting　in　high-quality　freshwater　production　with　a　90.13%　pure　water　recovery　from　landfill　leachate　concentrate　during　a　50　h　membrane　distillation-based　concentration　procedure　with　a　concentration　factor　of　10.13.　These　results　manifested　the　superhydrophobic　PVDF　membrane　as　a　promising　avenue　for　pure　water　production　from　complex　waste　streams　via　membrane　distillation.　©　2024　American　Chemical　Society.