Trauma　is　a　significant　health　issue　that　not　only　leads　to　immediate　death　in　many　cases　but　also　causes　severe　complications,　such　as　sepsis,　thrombosis,　haemorrhage,　acute　respiratory　distress　syndrome　and　traumatic　brain　injury,　among　trauma　patients.　Target　protein　identification　technology　is　a　vital　technique　in　the　field　of　biomedical　research,　enabling　the　study　of　biomolecular　interactions,　drug　discovery　and　disease　treatment.　It　plays　a　crucial　role　in　identifying　key　protein　targets　associated　with　specific　diseases　or　biological　processes,　facilitating　further　research,　drug　design　and　the　development　of　treatment　strategies.　The　application　of　target　protein　technology　in　biomarker　detection　enables　the　timely　identification　of　newly　emerging　infections　and　complications　in　trauma　patients,　facilitating　expeditious　medical　interventions　and　leading　to　reduced　post-trauma　mortality　rates　and　improved　patient　prognoses.　This　review　provides　an　overview　of　the　current　applications　of　target　protein　identification　technology　in　trauma-related　complications　and　provides　a　brief　overview　of　the　current　target　protein　identification　technology,　with　the　aim　of　reducing　post-trauma　mortality,　improving　diagnostic　efficiency　and　prognostic　outcomes　for　patients.