In　this　work,　we　present　a　reverse-design　method　for　1-D　disordered　waveguide　structures　which　might　be　used　for　future　terahertz　on-chip　integrated　systems.　This　method　is　based　on　the　Anderson　localization　effect　to　construct　the　initial　structure　of　the　waveguides.　Due　to　the　probability　statistical　distribution,　the　waveguides　with　randomly　generated　fluctuations　have　different　localization　abilities.　We　optimized　the　refractive　index　fluctuations　and　distributions　of　the　waveguide　structure　through　intelligent　reverse-design　algorithms　and　ultimately　obtained　the　optimal　structural　parameters.　Simulation　results　indicate　that　the　optimized　waveguide　has　a　better　localization　ability,　a　lower　insertion　loss,　and　a　good　robustness　against　fabrication　errors　and　defects　compared　to　the　initial　waveguide.