In　order　to　study　the　high-order　effect　of　high-rise　foundation　isolation　structure　and　its　control　method,　the　working　mechanism　of　high-order　effect　of　high-rise　foundation　isolation　structure　is　revealed.　Seismic　shaking　table　test　was　carried　out　based　on　a　1　/　15　scaled　practical　project,　and　a　finite　element　model　was　established.　The　acceleration　and　displacement　responses　were　obtained　by　time　history　analysis　method.　The　effectiveness　of　the　finite　element　model　was　verified　by　comparing　the　analysis　results　with　the　test　data.　The　results　show　that,　under　certain　conditions,　the　higher　part　of　the　high-rise　foundation　isolation　structure　may　produce　obvious　high-order　effect,　and　the　mutation　layer　is　basically　located　at　the　place　where　the　mass　ratio　of　the　higher　part　to　the　total　mass　of　the　structure　is　about　1　/　5.　Under　action　of　8　dagree　rare　earthquakes,　the　acceleration　amplification　coefficient　at　the　top　of　the　structure　is　larger　than　2,　and　the　interlayer　displacement　angle　near　the　mutation　layer　is　larger　than　1　/　100.　Both　the　proposed　base-TMD　hybrid　isolation　scheme　and　the　base-floor　hybrid　isolation　scheme　can　effectively　solve　the　high-order　effect　of　the　high-rise　foundation　isolation　structure,　among　which　the　vibration　control　effect　of　the　base-TMD　hybrid　isolation　scheme　can　reach　about　50%　.　The　optimal　isolation　effect　of　base-layer　mixed　isolation　scheme　is　close　to　50%　.　©　2023　Science　Press.　All　rights　reserved.