In　this　paper,　porous　hollow　silica　nanoparticles　(HSNS)　have　been　successfully　fabricated　by　a　novel　combination　of　stabilizing　condensation　and　dynamic　self-assembly.　In　composition,　porous　silica　nanoparticles　(MSNS-1,　MSNS-2)　and　porous　silica　nanocapsules　(SNC)　were　successfully　synthesized.　The　silica　nanostructures　were　characterized　by　small-angle　X-ray　diffraction,　scanning　electron　microscopy,　transmission　electron　microscopy,　and　nitrogen　adsorption-desorption　measurements.　HSNS　have　higher　specific　surface　areas　and　large　pore　volumes　than　MSNS　and　SNC.　The　formation　mechanism　of　the　silica　nanostructures　was　discussed.　Further,　encapsulation　of　organic　molecules　into　HSNS　and　their　controlled　release　were　investigated　by　using　Doxorubicin　(DOX)　as　a　model.　HSNS　show　excellent　drug　delivery　properties.　DOX-loaded　silica　nanostructures　exhibit　superb　drug　release　behavior,　which　is　controlled　by　varying　the　pH.　The　current　approaches　will　doubtlessly　open　many　possibilities　toward　biological　and　technological　applications　of　silica　nanomaterials.　(C)　2011　Elsevier　Inc.　All　rights　reserved.