In　this　study,　the　Bi2O2CO3-Cu2O　composite　has　been　fabricated　via　a　facile　in-situ　coprecipitation　way　and　then　a　novel　photocatalytic　film　SF/Bi2O2CO3-Cu2O　has　been　first　prepared　by　electrospinning.　The　as-prepared　materials　were　characterized　by　XRD,　XPS,　SEM,　TEM,　FTIR　and　UV-vis,　etc.　technologies.　The　formation　of　Bi2O2CO3-Cu2O　heterostructure　was　conducive　to　the　separation　and　transport　of　carriers,　and　thus　enhancing　visible-light-driven　photocatalytic　property.　Accordingly,　the　highest　photodegradation　efficiency　of　SF/Bi2O2CO3-Cu-2　O　for　chloramphenicol　achieved　98.3%　in　30　min,　which　was　much　higher　than　that　of　SF/Bi2O2CO3.　Concurrently,　the　SF/Bi2O2CO3-Cu2O　nanofiber　can　easily　separate　from　the　water　due　to　its　selfsupporting　structure　provided　by　electrospinning　silk　fibroin.　According　to　the　photodegradation　mechanism　and　the　analysis　of　degradation　products　measured　by　Q-TOF,　we　also　proposed　the　possible　degradation　pathways　of　chloramphenicol.　It　was　found　that　the　S.　aureus　and　E.　coli　growth　suppressed　by　71.09%　and　80.63%　respectively　after　SF/Bi2O2CO3　-Cu2O　treatment.　Finally,　we　have　proved　the　low-cytotoxicity　of　the　membrane　through　the　Cell　Counting　Kit-8　method.