The　pyrene-appended　dipicolylamine　ligand　(L)　and　its　Cu(II)　and　Pt(II)　compounds　have　been　synthesized　and　characterized　by　elemental　analysis,　H-1-　and　C-13-NMR,　HRMS,　FT-IR　andUV-Vis　analyses.　Furthermore,　the　crystal　structures　of　H2L　center　dot　2ClO(4),　[(CuLClO4CH3CN)ClO4]　and　[(PtLCl)DMSO]　(DMSO　=　dimethyl　sulfoxide)　have　been　determined　by　single-crystal　X-ray　diffraction.　The　antimicrobial　activities　of　these　compounds　were　determined　towards　Gram-positive　(Staphylococcus　aureus　ATCC-25923)　and　Gram-negative　(Escherichia　coli　ATTC-25922)　trains　of　bacteria,　as　well　as　the　fungal　strain　Candida　albicans　ATCC-10213,　and　the　results　were　compared　with　those　of　L　alone.　The　results　of　these　experiments　showed　that　the　Cu(II)　and　Pt(II)　compounds　of　L　exhibited　stronger　antibacterial　and　antifungal　activities　than　the　ligand.