Metallic　Zn　has　been　regarded　as　ideal　anodes　in　aqueous　electrolyte　owing　to　its　high　theoretical　capacity,　intrinsic　safety,　low　cost,　and　nontoxicity.　However,　the　Zn　dendrite　growth　and　the　side-reactions　hindered　the　practical　application　of　Zn　anode.　Herein,　a　thin　and　uniform　three-dimensional　(3D)　COOH-functionalized　covalent　organic　frameworks　(COF)　film　(denoted　as　3D-COOH-COF)　is　designed　and　in-situ　synthesized　as　a　protective　layer　to　stabilize　the　Zn　anode.　The　thin　3D-COOH-COF　protection　film　with　abundant　negative　functional　groups　and　homogeneous　nanochannels　facilitates　the　fast　transport　of　Zn2+,　impedes　the　pass　through　of　SO42-　,　and　significantly　suppresses　the　corrosion　reactions,　leading　to　an　excellent　electrochemical　performance.　The　novel　3D-COOH-COF　protective　film　enables　the　Zn||Zn　symmetric　cells　to　stably　cycle　for　over　2000　h　at　1　mA　cm-2　and　an　average　Coulombic　efficiency　of　Zn　plating/stripping　as　high　as　99.5%　for　1000　cycles　at　1　mA　cm-　2.This　finding　provides　a　facile　and　promising　route　to　regulate　the　deposition　behavior　of　Zn　in　aqueous　electrolyte.