The　zoning　characteristics　of　alteration　and　mineralization　are　the　key　to　establish　the　deposit　model　and　prospecting　prediction　of　the　porphyry-epithermal　copper-gold　metallogenic　system.　The　Čukaru　Peki　is　a　newly　discovered　giant　porphyry-epithermal　copper-gold　deposit　(upper　zone:　copper　1.54　million　tons　@　2.45%,　gold　86　t　@　1.37　g/t,　lower　zone:　copper　14.28　million　tons　@　0.83%,　gold　295　tons　@　0.17　g/t)　in　Timok,　Serbia,　Western　Tethys.　The　orebodies　are　mainly　hosted　in　the　late　Cretaceous　plagioclase　andesite,　and　research　on　its　alteration　and　mineralization　zoning　characteristics　and　prospecting　potential　is　rare.　In　this　paper,　we　integrated　drill　hole　logging　with　short-wavelength　infrared　(SWIR)　spectral　analysis,　microscopic　observation,　and　sulfide　EMPA　results　of　rock　and　ore　samples,　and　the　characteristics　of　hydrothermal　alteration　and　sulfide　zoning　were　determined,　and　its　implication　for　exploration　was　discussed.　We　found　that　the　deposit　has　zoning　characteristics　of　high-sulfidation　epithermal　copper-gold　mineralization　in　the　upper　part,　transitional　copper-gold　mineralization　in　the　middle　part,　and　porphyry　copper-gold　mineralization　in　the　lower　part.　The　zoning　characteristics　of　hydrothermal　alteration　in　the　mining　area　are　apparent.　The　porphyry　intrusion　is　the　centre　of　the　porphyry-type　copper-gold　mineralization,　and　potassic　alteration　zone,　propylitic　alteration　zone,　chlorite-white　mica　zone,　and　quartz-white　mica-zone　are　developed　sequentially　outwards.　The　wavelength　of　the　white　mica　SWIR　Al-OH　2200　nm　peak　position　in　the　chlorite-white　mica　zone　is　generally　higher　than　that　in　the　quartz-white-mica　zone.　The　transitional　mineralization　develops　diaspore-pyrophyllite　alterations　and　dickite-kaolinite　superimposed　with　phyllic　alterations.　The　upper　high-sulfidation　epithermal　copper-gold　mineralization　develops　advanced　argillic,　which　can　be　divided　into　quartz-alunite,　dickite-kaolinite　and　montmorillonite　from　inside　outside.　Metallic　mineral　assemblages　also　have　prominent　zoning　characteristics:　the　deep　to　shallow　zonation　of　chalcopyrite　+　bornite　→　chalcopyrite　+　pyrite　+　(magnetite　±　hematite)　for　the　lower　porphyry　copper-gold　mineralization;　the　mainly　tennantite　+　(bornite　+　chalcopyrite　+　digenite　+　covellite)　for　the　transitional　copper-gold　mineralization;　enargite　+　covellite　for　the　upper　high-sulfidation　epithermal　copper-gold　type　mineralization.　Overall,　the　lower　part　of　the　ore　deposit　is　a　Cu-Fe-S　system,　the　middle　part　runs　through　the　Cu-As-Sb-S　system,　and　it　transforms　upwards　into　a　Cu-S　system.　The　sulfide　assemblage　changes　from　the　high-temperature　and　low-sulfidation　state　in　the　deep　early　stage　to　the　low-temperature　and　high-sulfidation　state　in　the　mid-shallow　at　the　late　stages.　In　summary,　combined　with　the　geochemical　data,　we　established　a　hydrothermal　alteration　and　sulfide　assemblage　zoning　model　and　speculated　that　there　is　an　excellent　mineralization　potential　in　the　northwestern　and　deep　part　of　the　Čukaru　Peki　copper-gold　deposit.　This　model　presented　may　have　important　implications　for　deep　exploration　of　the　Zijinshan　gold-copper　deposit　and　late　Cretaceous　porphyry-epithermal　copper-gold　deposits　in　the　Gangdise　metallogenic　belts.　©　2023　Science　Press.　All　rights　reserved.