Medical　adhesives　are　advanced　but　challenging　alternatives　to　wound　closure　and　repair,　especially　in　mitigating　uncontrolled　hemorrhage.　Ideal　hemostatic　adhesives　need　to　meet　good　biocompatibility　and　biodegradability,　adequate　mechanical　strength,　and　strong　tissue　adhesion　functionality　under　wet　and　dynamic　conditions.　Considering　these　requirements,　natural　polymers　such　as　polysaccharide,　protein　and　DNA,　attract　great　attention　as　candidates　for　making　bioadhesives　because　of　their　distinctive　physicochemical　performances　and　biological　properties.　This　review　systematically　summarizes　the　advances　of　bioadhesives　based　on　natural　polysaccharide,　protein　and　DNA.　Various　physical　and　chemical　cross-linking　strategies　have　been　introduced　for　adhesive　synthesis　and　their　hemostatic　applications　are　introduced　from　the　aspect　of　versatility.　Furthermore,　the　possible　challenges　and　future　opportunities　of　bioadhesives　are　discussed,　providing　insights　into　the　development　of　high-performance　hemostatic　materials.　©　2023