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Inventor:

高瑜 (高瑜.) [1] (Scholars:高瑜) | 李旭东 (李旭东.) [2] | 王玉然 (王玉然.) [3] | 郑怡琳 (郑怡琳.) [4] | 陈海军 (陈海军.) [5] (Scholars:陈海军)

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Abstract:

本发明公开了一种低氧响应的壳聚糖聚合物及其制备方法与应用。本发明通过点击化学的方法,将低氧响应基团偶氮苯、氟硼二吡咯(BODIPY)光敏剂与壳聚糖共价连接,形成具有低氧响应特性的壳聚糖聚合物。该聚合物不仅可以有效降低光敏剂的光毒性,提高光敏剂的稳定性,还可在肿瘤低氧微环境中实现低氧响应成像,且其可作为载体包载疏水性药物,并使药物在肿瘤部位靶向释放,从而促进药物在肿瘤部位的聚集。

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Patent Info :

Type: 发明授权

Patent No.: CN202210037127.5

Filing Date: 2022-01-13

Publication Date: 2022-12-13

Pub. No.: CN114369175B

公开国别: 中国

Applicants: 福州大学

Legal Status: 授权

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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