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学者姓名：高瑜
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Abstract ：
Heptamethine indocyanine dyes (HMICDs) have excellent near-infrared (NIR) properties and are capable of converting light energy into heat energy under NIR laser irradiation, enabling their use in photothermal therapy (PTT) of tumors. However, their photostability is poor, and they are easily inactivated by photobleaching after prolonged and repeated exposure to NIR laser. In addition, unmodified HMICDs have poor water solubility and tend to aggregate, limiting their biological applications. Herein, we designed and synthesized HMICDs with hydrophilic side chains and different substituent groups on polymethine chain, and explored the effects of these modifications on the water solubility, photostability and photothermal properties of the dyes. The introduction of tri-ethylene glycol hydrophilic side chains can improve the water solubility of HMICDs, and enhance the photostability and photothermal properties by increasing the spatial hindrance of the dyes. Furthermore, the incorporation of substituents with strong electron-withdrawing ability into the polymethine chain can improve the photostability and photothermal effect of the dyes. Under laser irradiation, the dyes can inhibit the proliferation of tumor cells by enhancing intracellular reactive oxygen species levels, decreasing mitochondrial membrane potential, and inducing cell apoptosis. In two tumor-bearing mouse models, dye 11 can effectively inhibit tumor growth by exerting photothermal effects with good biosafety. This work can provide a research foundation for the subsequent construction of HMICDs-based photothermal therapeutic agents for clinical applications.
Keyword ：
Heptamethine indocyanine dyes Heptamethine indocyanine dyes Photostability Photostability Photothermal therapy Photothermal therapy Water solubility Water solubility
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| GB/T 7714 | Shen, Xinyi , Yu, Jing , Chen, Tingyan et al. Structural modification of heptamethine indocyanine dyes with improved aqueous solubility and stability for photothermal therapy [J]. | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , 2025 , 290 . |
| MLA | Shen, Xinyi et al. "Structural modification of heptamethine indocyanine dyes with improved aqueous solubility and stability for photothermal therapy" . | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 290 (2025) . |
| APA | Shen, Xinyi , Yu, Jing , Chen, Tingyan , Sun, Xianbin , Long, Haixin , Du, Manyi et al. Structural modification of heptamethine indocyanine dyes with improved aqueous solubility and stability for photothermal therapy . | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , 2025 , 290 . |
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Despite significant advances in diverse cancer treatment methods, chemotherapy remains the primary approach, and the development of chemoresistance is still a persistent problem during treatment. Here, we developed a derivative of the natural product mangiferin as a carrier for delivering chemotherapeutic drug, aiming to overcome drug resistance through a distinctive four-pronged strategy, including modulation of inflammatory tumor microenvironment (TME), induction of ferroptosis, deep tumor penetration, and the combinatory anticancer effects. After clarifying the promotion effects of the cancer associated fibroblasts (CAFs) in chemoresistance, and leveraging our previous elucidation of the anti-inflammatory and ferroptosis-inducing ability of mangiferin, we synthesized mangiferin amphiphile (MMF) and developed a self-assembled carrier-free nanomedicine, named MP, through the self-assembly of MMF and the representative chemotherapeutic drug paclitaxel (PTX). MP possessed a particle size of approximately 68 nm with compact filamentous nanostructures. MP demonstrated efficient tumor-targeting and deep tumor penetration abilities. Furthermore, MP effectively suppressed glutathione peroxidase 4 (GPX4) expression to induce ferroptosis, mitigated the activation of IL-6/STAT3 pathway to deactivate CAFs within the inflammatory TME, and exhibited robust anti-cancer effects against PTXresistant breast cancer both in vitro and in vivo. This mangiferin derivative represents a promising "all-in-one" nanocarrier for delivering chemotherapeutic drugs, offering a green, safe, and convenient self-assembled carrierfree nanomedicine to effectively overcome drug resistance.
Keyword ：
CAFs CAFs Carrier-free nanomedicine Carrier-free nanomedicine Drug resistance Drug resistance Ferroptosis Ferroptosis Inflammatory tumor microenvironment Inflammatory tumor microenvironment
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| GB/T 7714 | Zheng, Yilin , Xu, Ruofei , Chen, Tingyan et al. Four-pronged reversal of chemotherapy resistance by mangiferin amphiphile [J]. | JOURNAL OF CONTROLLED RELEASE , 2025 , 378 : 776-790 . |
| MLA | Zheng, Yilin et al. "Four-pronged reversal of chemotherapy resistance by mangiferin amphiphile" . | JOURNAL OF CONTROLLED RELEASE 378 (2025) : 776-790 . |
| APA | Zheng, Yilin , Xu, Ruofei , Chen, Tingyan , Wang, Ya , Chen, Xiaoye , Chen, Haijun et al. Four-pronged reversal of chemotherapy resistance by mangiferin amphiphile . | JOURNAL OF CONTROLLED RELEASE , 2025 , 378 , 776-790 . |
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The challenging treatment outcomes for nonsmall cell lung cancer (NSCLC) necessitate the development of innovative therapeutic strategies. In this work, we developed a multifunctional nanoplatform by modifying mesoporous silica nanoparticles (MSNs) with an aptamer (Apt) targeting epidermal growth factor (EFGR), and coloading a sonosensitizer, hematoporphyrin (HP), along with the natural nitric oxide (NO) donor, l-arginine (l-Arg). The resulting Apt-modified MSN loaded with l-Arg and HP (designated as AMLH) was designed for the targeted gas-assisted sonodynamic therapy (SDT) of NSCLC. AMLH exhibited an appropriate particle size, good drug loading ability, and ultrasound-responsive drug release. The coloading of HP and l-Arg resulted in higher encapsulation efficiency compared to single-drug loading, and AMLH remained stable when stored at 4 degrees C for 15 days. AMLH was capable of generating reactive oxygen species (ROS) and NO under ultrasound stimulation, leading to the further production of peroxynitrite (ONOO-). AMLH demonstrated specific targeting and recognition of EGFR-positive NSCLC cells, with preincubation of free Apt reducing cellular uptake, confirming the specificity of the Apt-functionalized nanoparticles. Cellular distribution studies revealed that AMLH was primarily localized in lysosomes after internalization. MTT assays and live/dead cell staining confirmed the superior cytotoxicity of AMLH, which effectively inhibits cell proliferation through mitochondrial membrane potential collapse and nuclear damage under ultrasound stimulation. These results highlight the combined efficacy of EGFR targeting, SDT, and NO gas therapy, offering a promising strategy to improve the NSCLC treatment outcomes.
Keyword ：
aptamer aptamer nitricoxide nitricoxide nonsmallcell lung cancer nonsmallcell lung cancer peroxynitrite peroxynitrite sonodynamic therapy sonodynamic therapy
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| GB/T 7714 | Zheng, Fangying , Zhang, Peixia , Zhang, Yinglu et al. Aptamer-Modified Mesoporous Silica Nanoparticle for Nitric Oxide-Enhanced Targeted Sonodynamic Therapy against Lung Cancer [J]. | ACS APPLIED NANO MATERIALS , 2025 , 8 (10) : 5179-5192 . |
| MLA | Zheng, Fangying et al. "Aptamer-Modified Mesoporous Silica Nanoparticle for Nitric Oxide-Enhanced Targeted Sonodynamic Therapy against Lung Cancer" . | ACS APPLIED NANO MATERIALS 8 . 10 (2025) : 5179-5192 . |
| APA | Zheng, Fangying , Zhang, Peixia , Zhang, Yinglu , Long, Haixin , Zhu, Fangyin , Chen, Haijun et al. Aptamer-Modified Mesoporous Silica Nanoparticle for Nitric Oxide-Enhanced Targeted Sonodynamic Therapy against Lung Cancer . | ACS APPLIED NANO MATERIALS , 2025 , 8 (10) , 5179-5192 . |
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Photothermal therapy (PTT) is a promising noninvasive cancer treatment with high spatial-temporal selectivity and low systemic toxicity. However, its efficiency is restricted by the poor photostability, low tumor selectivity and inadequate deep tumor penetration of current photothermal agents. This study synthesized oleanolic acid (OA)-modified chitosan (CsO) using click chemistry and developed a nano-photothermal agent (COI) through the self-assembly of CsO and a representative photothermal agent indocyanine green (ICG). COI possessed a particle size of approximately 120 nm, good physical stability, and pH-responsive drug release properties. Under 808 nm laser irradiation, COI exhibited high photothermal conversion efficiency and photostability. The cellular uptake of COI in B16 and 4T1 cancer cells was several-fold higher than that of free ICG, while remaining comparable to ICG in normal 3T3 cells. CsO inhibited cancer-associated fibroblasts proliferation and modulated the tumor microenvironment by reducing alpha-smooth muscle actin expression, enhancing deep penetration of COI in threedimensional multicellular tumor spheres and solid tumors. The promising anti-proliferative effects of COI in vitro and in vivo indicated notable synergistic effects between the chemotherapeutic effect of OA and the photothermal therapeutic effect of ICG. These results suggest that COI could serve as a promising deep tumor-penetrating nanophotothermal agent for enhanced chemo-photothermal anticancer therapy.
Keyword ：
Chitosan Chitosan Deep penetration Deep penetration Oleanolic acid Oleanolic acid Photothermal therapy Photothermal therapy
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| GB/T 7714 | Zheng, Fangying , Tan, Ding , Zheng, Yilin et al. A chitosan-based deep tumor-penetrating nano-photothermal agent for enhanced chemo-photothermal combination therapy [J]. | MATERIALS TODAY CHEMISTRY , 2025 , 45 . |
| MLA | Zheng, Fangying et al. "A chitosan-based deep tumor-penetrating nano-photothermal agent for enhanced chemo-photothermal combination therapy" . | MATERIALS TODAY CHEMISTRY 45 (2025) . |
| APA | Zheng, Fangying , Tan, Ding , Zheng, Yilin , Chen, Haijun , Gao, Yu . A chitosan-based deep tumor-penetrating nano-photothermal agent for enhanced chemo-photothermal combination therapy . | MATERIALS TODAY CHEMISTRY , 2025 , 45 . |
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Photoredox catalysis has become a mainstay in synthetic methodology over the past decade. However, its application in the functionalization of natural products remains to be further explored. Herein, we report an efficient approach to synthesize artemisinin G from artemisinin via photocatalysis in high yield. Photoredox catalysis has become a mainstay in synthetic methodology over the past decade. Herein, an efficient method for the synthesis of artemisinin G from artemisinin by using 0.5 mol % of TBADT as the catalyst was reported. The reaction proceeds smoothly and rapidly (complete within 30 min) at room temperature in high yield. image
Keyword ：
Artemisinin Artemisinin Artemisinin G Artemisinin G Photocatalysis Photocatalysis Practical synthesis Practical synthesis Radical chemistry Radical chemistry
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| GB/T 7714 | Wang, Menghan , Liu, Xiaoling , Zheng, Xiaoshan et al. Synthesis of Artemisinin G from Artemisinin via Photocatalysis [J]. | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY , 2024 , 27 (15) . |
| MLA | Wang, Menghan et al. "Synthesis of Artemisinin G from Artemisinin via Photocatalysis" . | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 27 . 15 (2024) . |
| APA | Wang, Menghan , Liu, Xiaoling , Zheng, Xiaoshan , Luo, Yining , Gao, Yu , Chen, Haijun . Synthesis of Artemisinin G from Artemisinin via Photocatalysis . | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY , 2024 , 27 (15) . |
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Photothermal therapy (PTT) has attracted extensive attention in cancer treatment because of its advantages of non-invasive and few side effects. Gold nanoparticles and boron-fluorine-dipyrrole (BODIPY) dye have been used as photothermal agents (PTAs), but they have problems such as easy aggregation, poor water solubility and low photothermal conversion efficiency. In this work, we used conventional liposomes for in situ generation of small gold nanoparticles and sequentially loading BODIPY to overcome the drawbacks of the two PTAs and simultaneously realize enhanced PTT. Gold- and BODIPY-coordinated liposomal nanocomplexes LAB with small gold nanoparticles adsorbed on the surface and BODIPY entrapped inside showed uniform size of about 100 nm with good stability. LAB demonstrated laser-responsive drug release property, good cellular uptake efficiency and tumor accumulation ability. After laser irradiation, LAB can exert enhanced PTT in cancer cell lines by reducing mitochondrial membrane potential and increase intracellular reactive oxygen species level to promote cell apoptosis. In tumor-bearing mice, LAB showed fantastic tumor inhibition effect with good biosafety. This work provides a convenient method to develop PTA combinations for enhanced PTT, which could lay the foundation for the green construction of new PTAs for PTT by employing clinically used formulations and PTAs.
Keyword ：
Anti -tumor Anti -tumor BODIPY BODIPY Gold nanoparticles Gold nanoparticles Lipid nanocomplexes Lipid nanocomplexes Synergistic photothermal therapy Synergistic photothermal therapy
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| GB/T 7714 | Wang, Yuran , Li, Xudong , Wang, Ya et al. Facile construction of gold- and BODIPY-coordinated liposomal nanocomplexes for enhanced photothermal therapy of cancer [J]. | MATERIALS & DESIGN , 2024 , 241 . |
| MLA | Wang, Yuran et al. "Facile construction of gold- and BODIPY-coordinated liposomal nanocomplexes for enhanced photothermal therapy of cancer" . | MATERIALS & DESIGN 241 (2024) . |
| APA | Wang, Yuran , Li, Xudong , Wang, Ya , Chen, Haijun , Gao, Yu , Lin, Yuxiang . Facile construction of gold- and BODIPY-coordinated liposomal nanocomplexes for enhanced photothermal therapy of cancer . | MATERIALS & DESIGN , 2024 , 241 . |
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Photothermal therapy (PTT) has attracted extensive attention in cancer treatment. Heptamethine cyanine dyes with near-infrared (NIR) absorption performance have been investigated for PTT. However, they are often accompanied by poor photostability, suboptimal photothermal conversion and limited therapeutic efficacy. The photophysical properties of fluorescent organic salts can be tuned through counterion pairing. However, whether the counterion can influence the photostability and photothermal properties of heptamethine cyanine salts has not been clarified. In this work, we investigated the effects of eleven counter anions on the physical and photothermal properties of NIR-II heptamethine cyanine salts with the same heptamethine cyanine cation. The anions have great impacts on the physiochemical properties of dyes in solution including aggregation, photostability and photothermal conversion efficiency. The physical tuning enables the control over the cytotoxicity and phototoxicity of the dyes. The selected salts have been demonstrated to significantly suppress 4T1 breast tumor growth with low toxicity. The findings that the counterion has great effects on the photothermal properties of cationic NIR-II heptamethine cyanine dyes will provide a reference for the preparation of improved photothermal agents through counterion pairing with possible translation to humans.
Keyword ：
Counter anion Counter anion Heptamethine cyanine salts Heptamethine cyanine salts NIR-II NIR-II Photostability Photostability Photothermal therapy Photothermal therapy
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| GB/T 7714 | Zheng, Yilin , Chen, Tingyan , Gao, Yu et al. Counterion influence on near-infrared-II heptamethine cyanine salts for photothermal therapy [J]. | BIOORGANIC CHEMISTRY , 2024 , 145 . |
| MLA | Zheng, Yilin et al. "Counterion influence on near-infrared-II heptamethine cyanine salts for photothermal therapy" . | BIOORGANIC CHEMISTRY 145 (2024) . |
| APA | Zheng, Yilin , Chen, Tingyan , Gao, Yu , Chen, Haijun . Counterion influence on near-infrared-II heptamethine cyanine salts for photothermal therapy . | BIOORGANIC CHEMISTRY , 2024 , 145 . |
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Inorganic antimicrobial materials have the advantages of high safety, strong durability, stable antimicrobial performance, and good heat resistance compared with organic antimicrobial materials. In this study, Fe-doped small zinc oxide nanoparticles (FZO-NPs) with different iron contents were synthesized and then modified with 3-aminopropyltriethoxysilane (APTES) and poly(ethylene glycol)-600 (PEG-600) to afford FZO-APs. FZOAPs which were fully characterized can disperse in water with good dispersity and improved stability. In antimicrobial tests, FZO-AP4 displayed excellent antimicrobial effects under 10 min of 365 nm UV light against Gram-negative bacteria Escherichia coli (E. coli) and Gram-positive bacteria Staphylococcus aureus (S. aureus) with a minimum inhibitory concentration (MIC) of 0.20 and 0.15 mg/mL, respectively. The antimicrobial mechanism studies revealed that the consumption of glutathione (GSH) and ascorbic acid (ASA), and the generation of reactive oxygen species (ROS) could trigger lipid peroxidation (LPO) and ultimately induce ferroptosis in bacterial cells. The cause of the cell wall/membrane damage and the released Zn/Fe ions from the nanoparticles inside the bacterial cells further promote the antimicrobial effects. In addition, FZO-AP4 showed high inhibitory effects on bacterial biofilm formation and significantly disrupted the formed biofilm. Interestingly, higher bacterial biofilm residuals and bacterial survival were found in E. coli than in S. aureus after FZO-AP4 treatment, suggesting a potential link between the quorum sensing (QS) system of the bacteria and their different susceptibility towards FZO-AP4. This study proved the antibacterial effects of small water-soluble FZO-APs which is meaningful for the design and development of new inorganic nano-material for antimicrobial applications.
Keyword ：
Antimicrobial Antimicrobial Fe-doped ZnO Fe-doped ZnO Ferroptosis Ferroptosis Quorum sensing Quorum sensing ROS storm ROS storm
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| GB/T 7714 | Sun, Xianbin , Yu, Jing , Li, Xudong et al. Synthesis, characterization and antibacterial mechanism study of small water-soluble iron-doped zinc oxide nanoparticles [J]. | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS , 2024 , 686 . |
| MLA | Sun, Xianbin et al. "Synthesis, characterization and antibacterial mechanism study of small water-soluble iron-doped zinc oxide nanoparticles" . | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 686 (2024) . |
| APA | Sun, Xianbin , Yu, Jing , Li, Xudong , Chen, Haijun , Gao, Yu . Synthesis, characterization and antibacterial mechanism study of small water-soluble iron-doped zinc oxide nanoparticles . | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS , 2024 , 686 . |
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Non-invasive therapies such as photodynamic therapy (PDT) and chemodynamic therapy (CDT) have received wide attention due to their low toxicity and side effects, but their efficacy is limited by the tumor microenvironment (TME), and monotherapy cannot achieve satisfactory efficacy. In this work, a multifunctional nanoparticle co -assembled from oleanolic acid (OA), chlorin e6 (Ce6) and hemin was developed. The as -constructed nanoparticle named OCH with diameters of around 130 nm possessed good biostability, pH/GSH dual -responsive drug release properties, and remarkable cellular internalization and tumor accumulation capabilities. OCH exhibited prominent catalytic activities to generate center dot OH, deplete GSH, and produce O 2 to overcome the hypoxia TME, thus potentiating the photodynamic and chemodynamic effect. In addition, OCH can induce the occurrence of ferroptosis in both ferroptosis-sensitive and ferroptosis-resistant cancer cells. The multi -pronged effects of OCH including hypoxia alleviation, GSH depletion, ferroptosis induction, CDT and PDT effects jointly facilitate excellent anticancer effects in vitro and in vivo . Hence, this work will advance the development of safe and effective clinically transformable nanomedicine by employing clinically -applied agents to form drug combinations for efficient multi -pronged combination cancer therapy.
Keyword ：
Carrier -free Carrier -free Ferroptosis Ferroptosis Synergistic therapy Synergistic therapy Tri-component Tri-component Tumor microenvironment Tumor microenvironment
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| GB/T 7714 | Shi, Huifang , Zheng, Fangying , Zheng, Yilin et al. A carrier-free tri-component nanoreactor for multi-pronged synergistic cancer therapy [J]. | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY , 2024 , 253 . |
| MLA | Shi, Huifang et al. "A carrier-free tri-component nanoreactor for multi-pronged synergistic cancer therapy" . | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 253 (2024) . |
| APA | Shi, Huifang , Zheng, Fangying , Zheng, Yilin , Sun, Xianbin , Chen, Haijun , Gao, Yu . A carrier-free tri-component nanoreactor for multi-pronged synergistic cancer therapy . | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY , 2024 , 253 . |
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An efficient and rapid protocol for the oxidative halogenation of tryptamines with 10 % aqueous NaClO has been developed. This reaction is featured by its operational simplicity, metal-free conditions, no purification, and high yield. Notably, the resulting key intermediates are suitable for further functionalization with various nucleophiles, including amines, N-aromatic heterocycles, indoles and phenols. The overall transformation exhibits broad functional-group tolerance and is applicable to the late-stage functionalization of complex biorelevant molecules. An efficient and rapid protocol for the oxidative halogenation of tryptamines with 10 % aqueous NaClO has been developed. This reaction is featured by its operational simplicity, metal-free conditions, no purification, and high yield. The overall transformation exhibits broad functional-group tolerance and is applicable to the late-stage functionalization of complex biorelevant molecules. image
Keyword ：
Autophagy Autophagy Drug discovery Drug discovery Green chemistry Green chemistry Late-stage functionalization Late-stage functionalization Tryptamines Tryptamines
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| GB/T 7714 | Xu, Jiayi , Zhang, Yahui , Cai, Qiling et al. Green Late-Stage Functionalization of Tryptamines [J]. | CHEMISTRY-A EUROPEAN JOURNAL , 2024 , 30 (46) . |
| MLA | Xu, Jiayi et al. "Green Late-Stage Functionalization of Tryptamines" . | CHEMISTRY-A EUROPEAN JOURNAL 30 . 46 (2024) . |
| APA | Xu, Jiayi , Zhang, Yahui , Cai, Qiling , Chen, Li , Sun, Yang , Liu, Qinying et al. Green Late-Stage Functionalization of Tryptamines . | CHEMISTRY-A EUROPEAN JOURNAL , 2024 , 30 (46) . |
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