Fouling　control　is　the　most　critical　concern　in　the　implementation　of　nanofiltration　(NF)　for　dye　wastewater　treatment.　In　this　study,　integration　of　NF　and　Fenton-like　advanced　oxidation　was　realized　by　tailoring　a　thin　film　composite　NF　membrane　(TFNi)　with　in　situ　synthesized　PDA/MnO2　interlayer.　TFNi　was　optimized　by　controlling　the　amount　of　MnO2　nanoparticles　incorporated　within　the　interlayer　which　endowed　the　membrane　with　self-cleaning　property.　Besides　it　improved　the　membrane　surface　hydrophilicity　and　optimized　the　water　transport　path,　resulting　in　alleviated　fouling　risks　and　an　enhanced　water　permeance　of　24　+/-　2　L　m-　2　h-1　bar-1　compared　to　the　control　membrane.　Fouling　and　subsequent　chemical　cleaning　experiments　were　carried　out　on　TFNi　under　various　water　chemistry　conditions　to　elucidate　the　underlying　mechanisms　governing　the　self-cleaning　properties.　Accordingly,　a　high　flux　recovery　ratio　(FRR)　(above　95%)　was　maintained　thanks　to　the　generation　of　free　radicals　by　MnO2-H2O2　system　which　was　validated　by　determining　the　free　radical　scav-enging　activities.　Moreover,　the　interlayer　confined　radicals　can　facilitate　the　decomposition　of　foulants　on　TFNi.　Conclusively,　H2O2-initiated　self-cleaning　of　TFNi　can　be　of　great　prospect　for　the　efficient　treatment　of　dye　wastewater　via　in-situ　generated　free　radicals.