Antibacterial　photodynamic　therapy　(aPDT)　is　regarded　as　one　of　the　most　promising　antibacterial　therapies　due　to　its　nonresistance,　noninvasion,　and　rapid　sterilization.　However,　the　development　of　antibacterial　materials　with　high　aPDT　efficacy　is　still　a　long-standing　challenge.　Herein,　we　develop　an　effective　antibacterial　photodynamic　composite　UiO-66-(SH)2@TCPP@AgNPs　by　Ag　encapsulation　and　4,4′,4″,4-(porphine-5,10,15,20-tetrayl)tetrakis(benzoic　acid)　(TCPP)　dopant.　Through　a　mix-and-match　strategy　in　the　self-assembly　process,　2,5-dimercaptoterephthalic　acid　containing　-SH　groups　and　TCPP　were　uniformly　decorated　into　the　UiO-66-type　framework　to　form　UiO-66-(SH)2@TCPP.　After　Ag(I)　impregnation　and　in　situ　UV　light　reduction,　Ag　NPs　were　formed　and　encapsulated　into　UiO-66-(SH)2@TCPP　to　get　UiO-66-(SH)2@TCPP@AgNPs.　In　the　resulting　composite,　both　Ag　NPs　and　TCPP　can　effectively　enhance　the　visible　light　absorption,　largely　boosting　the　generation　efficiency　of　reactive　oxygen　species.　Notably,　the　nanoscale　size　enables　it　to　effectively　contact　and　be　endocytosed　into　bacteria.　Consequently,　UiO-66-(SH)2@TCPP@AgNPs　show　a　very　high　aPDT　efficacy　against　Gram-negative　and　Gram-positive　bacteria　as　well　as　drug-resistant　bacteria　(MRSA).　Furthermore,　the　Ag　NPs　were　firmly　anchored　at　the　framework　by　the　high　density　of　-SH　moieties,　avoiding　the　cytotoxicity　caused　by　the　leakage　of　Ag　NPs.　By　in　vitro　experiments,　UiO-66-(SH)2@TCPP@AgNPs　show　a　very　high　antibacterial　activity　and　good　biocompatibility　as　well　as　the　potentiality　to　promote　cell　proliferation.　©　2023　American　Chemical　Society.