Photophysical and photochemical properties of α-(8-quinolinoxy) zinc phthalocyanine for photodynamic therapy - Details

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EI Scopus

Abstract：

The　photophysical　and　photochemical　properties　of　a　newly　developed　photosensitizer　α-(8-quinolinoxy)　zinc　phthalocyanine　(α-(8-QLO)　PcZn)　were　investigated　for　application　in　photodynamic　therapy　(PDT).　The　maximal　Q　band　for　α-(8-QLO)PcZn　in　dimethylformamide　around　675　nm　with　the　molar　extinction　coefficient　of　about　1.89105　mol-1cm　-1.　The　fluorescence　quantum　and　singlet　oxygen　(1O2)　yields　were　determined　to　be　0.180.02　and　0.620.03,　respectively.　α-(8-QLO)　PcZn　has　a　diffuse　cytoplasmic　distribution　in　nasopharyngeal　carcinoma　C666-1　cells,　and　the　efficient　photodynamic　cytotoxicity　was　observed.　Our　findings　of　this　study　suggest　that　α-(8-QLO)PcZn　is　a　promising　second-generation　photosensitizer　for　PDT.　©　2009　SPIE.

Keyword：

Cell proliferation Dimethylformamide Photodynamic therapy Photosensitizers Tumors Zinc Zinc compounds

Community：

[ 1 ] [Yuehui, Lv]Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian, 350007, China
[ 2 ] [Songlin, Yu]Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian, 350007, China
[ 3 ] [Huiyun, Lin]Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian, 350007, China
[ 4 ] [Buhong, Li]Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian, 350007, China
[ 5 ] [Jinping, Xue]Institute of Functional Materials, School of Chemistry and Chemical Engineering, Fuzhou University, Fujian 350003, P.R., China
[ 6 ] [Shusen, Xie]Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian, 350007, China