Hydrogels　with　great　biocompatibility,　biodegradability,　and　mechanical　properties,　combined　with　osteoconductivity,　osteoinductivity,　and　osteointegration　as　biomaterials　for　bone　regeneration　without　adding　exogenous　growth　factors　and　cells　are　highly　appealing　but　challenging.　Here,　inspired　by　organic-inorganic　analogues　of　natural　bone　tissue　and　the　adhesion　chemistry　of　mussels,　nanocomposite　hydrogels　with　self-healing,　injectable,　adhesive,　antioxidant,　and　osteoinductive　properties　(termed　GO-PHA-CPs)　were　constructed　by　Schiff　base　cross-linking　between　dopamine-modified　gelatin　(Gel-DA)　and　oxidized　dextran　(ODex).　Furthermore,　the　hydrogel　network　was　enhanced　by　the　introduction　of　polydopamine-functionalized　nanohydroxyapatite　(PHA)　by　improving　the　interfacial　compatibility　between　the　rigid　inorganic　particles　and　the　flexible　hydrogel　matrix.　Bioactive　cod　peptides　(CPs)　with　osteogenic　activity　from　Atlantic　cod　were　further　incorporated　into　the　nanocomposite　hydrogel.　As　a　result,　the　multicomponent　nanocomposite　hydrogel　favored　the　adhesion　and　spreading　of　MC3T3-E1　cells.　The　increased　ALP　activity　suggested　that　GO-PHA-CPs　hydrogels　contributed　to　the　osteogenic　differentiation　of　MC3T3-E1　cells.　The　suitability　of　GO-PHA-CPs　hydrogels　for　enhancing　bone　regeneration　in　vivo　was　further　confirmed　by　the　rat　femoral　defect　model.　Our　results　indicate　that　the　multifunctional　GO-PHA-CPs　nanocomposite　hydrogels　without　growth　factors　are　a　promising　and　effective　candidate　material　for　bone　regeneration.　©　2023