Bone　is　consisted　of　bone　matrix,　cells　and　bioactive　factors,　and　bone　matrix　is　the　combination　of　inorganic　minerals　and　organic　polymers.　Type　I　collagen　fibril　made　of　five　triple-helical　collagen　chains　is　the　main　organic　polymer　in　bone　matrix.　It　plays　an　important　role　in　the　bone　formation　and　remodeling　process.　Moreover,　collagen　is　one　of　the　most　commonly　used　scaffold　materials　for　bone　tissue　engineering　due　to　its　excellent　biocompatibility　and　biodegradability.　However,　the　low　mechanical　strength　and　osteoinductivity　of　collagen　limit　its　wider　applications　in　bone　regeneration　field.　By　incorporating　different　biomaterials,　the　properties　such　as　porosity,　structural　stability,　osteoinductivity,　osteogenicity　of　collagen　matrixes　can　be　largely　improved.　This　review　summarizes　and　categorizes　different　kinds　of　biomaterials　including　bioceramic,　carbon　and　polymer　materials　used　as　components　to　fabricate　collagen　based　composite　scaffolds　for　bone　regeneration.　Moreover,　the　possible　directions　of　future　research　and　development　in　this　field　are　also　proposed.　(c)　2017　The　Authors.　Production　and　hosting　by　Elsevier　B.V.　on　behalf　of　KeAi　Communications　Co.,　Ltd.