Emodin　is　applied　as　an　antitumor　drug　in　many　tumor　therapies.　However,　its　pharmacology　performances　are　limited　due　to　its　low　solubility.　Herein,　we　fused　erythrocyte　and　macrophage　to　form　a　hybrid　membrane　(EMHM)　and　encapsulated　emodin　to　form　hybrid　membrane-coated　nanoparticles.　We　employed　glycyrrhizin　to　increase　the　solubility　of　emodin　first　and　prepared　the　hybrid　membrane　nanoparticle-coated　emodin　and　glycyrrhizin　(EG@EMHM　NPs)　which　exhibited　an　average　particle　size　of　170　+/-　20　nm　and　encapsulation　efficiency　of　98.13　+/-　0.67%.　The　half-inhibitory　concentrations　(IC50)　of　EG@EMHM　NPs　were　1.166　mu　g/mL,　which　is　half　of　the　free　emodin.　Based　on　the　photosensitivity　of　emodin,　the　reactive　oxygen　species　(ROS)　results　disclosed　that　ROS　levels　of　the　photodynamic　therapy　(PDT)　section　were　higher　than　the　normal　section　(P　＜　0.05).　Compared　to　the　normal　section,　PDT-mediated　EG@EMHM　NPs　could　induce　an　early　stage　of　apoptosis　of　B16.　The　western　blot　and　flow　cytometry　results　verified　that　PDT-mediated　EG@EMHM　NPs　can　significantly　improve　the　solubility　of　emodin　and　perform　a　remarkably　antitumor　effect　on　melanoma　via　BAX　and　BCL-2　pathway.　The　application　of　the　combined　chemical　and　PDT　therapy　could　provide　an　improving　target　therapy　for　cutaneous　melanoma　and　also　may　offer　an　idea　for　other　insoluble　components　sources　of　traditional　Chinese　medicine.