Theutilization　of　modeling　tools　has　gained　significant　attentionrecently.　These　models　typically　involve　a　series　of　partial　differentialequations,　which　can　be　challenging　for　novice　modelers.　This　paperpresented　an　approach　in　practical　teaching　of　modeling　tools　forion-exchange　chromatography　with　three　parts:　model　introduction,model　calibration　through　group　learning　using　different　calibrationstrategies,　and　model　applications.　This　approach　was　integrated　intothe　traditional　bioseparation　engineering　curriculum　as　an　activity,using　the　separation　of　monomer-dimer　mixtures　of　monoclonalantibodies　as　an　example.　Results　of　competitive　group　learning　andthe　Wilcoxon　test　revealed　that　the　parameter-by-parameter　methodwas　more　user-friendly　than　the　Yamamoto　method　for　novice　modelersto　obtain　reasonable　model　parameters　quickly.　Then,　students　usedthe　well-fitted　model　for　process　optimization　and　explored　the　effectsof　process　parameters　and　material　input　variation　on　the　chromatographyprocess,　which　helped　students　appreciate　the　critical　role　of　timeand　material　savings　achieved　through　modeling　tools.　Finally,　thestudent　questionnaire　results　revealed　that　over　two-thirds　of　thestudents　gave　positive　feedback　on　the　activity.　Through　this　practicalteaching,　students　became　familiar　with　chromatography　modeling　tools,moving　away　from　the　tedious　formulaic　descriptions　found　in　traditionalmodeling　courses.　This　well-designed　activity　can　be　expanded　fromacademia　to　industry,　transforming　the　novice　modelers　into　experiencedmodelers　who　can　meet　the　high　demands　of　the　modern　biopharmaceuticalindustry.