Antibacterialphotodynamic　therapy　(aPDT)　is　regarded　as　one　ofthe　most　promising　antibacterial　therapies　due　to　its　nonresistance,noninvasion,　and　rapid　sterilization.　However,　the　development　ofantibacterial　materials　with　high　aPDT　efficacy　is　still　a　long-standingchallenge.　Herein,　we　develop　an　effective　antibacterial　photodynamiccomposite　UiO-66-(SH)(2)@TCPP@AgNPs　by　Ag　encapsulation　and4,4　&　PRIME;,4　&　DPRIME;,4＂＇-(porphine-5,10,15,20-tetrayl)tetrakis(benzoicacid)　(TCPP)　dopant.　Through　a　mix-and-match　strategy　in　the　self-assemblyprocess,　2,5-dimercaptoterephthalic　acid　containing　-SH　groupsand　TCPP　were　uniformly　decorated　into　the　UiO-66-type　framework　toform　UiO-66-(SH)(2)@TCPP.　After　Ag(I)　impregnation　and　insitu　UV　light　reduction,　Ag　NPs　were　formed　and　encapsulated　intoUiO-66-(SH)(2)@TCPP　to　get　UiO-66-(SH)(2)@TCPP@AgNPs.In　the　resulting　composite,　both　Ag　NPs　and　TCPP　can　effectively　enhancethe　visible　light　absorption,　largely　boosting　the　generation　efficiencyof　reactive　oxygen　species.　Notably,　the　nanoscale　size　enables　itto　effectively　contact　and　be　endocytosed　into　bacteria.　Consequently,UiO-66-(SH)(2)@TCPP@AgNPs　show　a　very　high　aPDT　efficacyagainst　Gram-negative　and　Gram-positive　bacteria　as　well　as　drug-resistantbacteria　(MRSA).　Furthermore,　the　Ag　NPs　were　firmly　anchored　at　theframework　by　the　high　density　of　-SH　moieties,　avoiding　thecytotoxicity　caused　by　the　leakage　of　Ag　NPs.　By　in　vitro　experiments,UiO-66-(SH)(2)@TCPP@AgNPs　show　a　very　high　antibacterialactivity　and　good　biocompatibility　as　well　as　the　potentiality　topromote　cell　proliferation.　A　Zr　MOF　compositeUiO-66-(SH)(2)@TCPP@AgNPs　wassuccessfully　synthesized　by　sequential　introduction　of　TCPP　and　incorporationof　ultrafine　Ag　NPs　into　the　UiO-66　type　framework,　whose　antibacterialphotodynamic　therapy　efficacy　was　significantly　enhanced.　Such　anantibacterial　photodynamic　therapy　efficacy　enhancement　is　mainlyascribed　to　the　promotion　of　ROS　generation,　endowing　the　compositewith　a　high　efficiency　in　killing　E.　coli　and　S.　aureus　as　well　as　drug-resistantbacteria　(MRSA).