Cross-linked　α-methylstyrene　maleic　anhydride　copolymer　microspheres　(PAMSM)　were　prepared　by　self-stable　precipitation　polymerization　with　α-methylstyrene　and　maleic　anhydride　as　copolymer　monomers　and　divinylbenzene　as　crosslinking　agent.　Firstly,　mono-6-p-toluenesulfonyl-　βcyclodextrin　(mono-6-OTs-β-CD)　was　obtained　by　the　monosulfonylation　of　β-cyclodextrin　(β-CD)　with　p-toluenesulfonyl　chloride,　and　then　1,2-propylenediamine-β-cyclodextrin　(PDM-β-CD)　was　achieved　by　the　ammoniating　of　mono-6-OTs-β-CD　with　excess　1,2-propylenediamine.　The　microspheres　of　β-CDPDM-PAMSM　were　prepared　though　immobilizing　PDM-　β　-CD　to　the　PAMSM　by　ringing-open　amidation　reaction　of　PDM-β-CD　with　the　primary　amines　and　PAMSM　with　the　anhydride　groups.　The　composition,　surface　morphology,　particle　size　and　distribution　of　the　β-CD-PDM-PAMSM　were　characterized　by　Fourier　transform　infrared　spectroscopy　(FTIR),　scanning　electron　microscopy　(SEM)　and　elemental　analysis.　The　results　showed　that　the　β-CD-PDM-PAMSM　maintained　good　sphericity　and　the　average　particle　size　was　1.08µm.　The　immobilization　yield　of　β-CD　on　PAMSM　was　high,　and　the　grafting　rate　of　β-CD　was　53.1%　calculated　by　the　elemental　analysis.　Then,　the　adsorption　properties　for　methylene　blue　solution　(MB)　of　PAMSM,　β-CD-PDM-PAMSM,　hydrolyzed　PAMSM　(H-PAMSM)　and　hydrolyzed　β-CDPDM-PAMSM　(H-β-CD-PDM-PAMSM)　were　investigated.　Research　suggested　that　the　adsorption　capacity　of　PAMSM　for　MB　was　25.3mg/g,　and　the　adsorption　capacity　of　β-CD-PDM-PAMSM　for　MB　was　615.8%　higher　than　that　of　PAMSM.　The　adsorption　capacity　of　H-β-CD-PDM-PAMSM　and　H-PAMSM　for　MB　was　1043.5%　and　860.8%　higher　than　that　of　PAMSM,　respectively.　©　2023　Chemical　Industry　Press.　All　rights　reserved.