As　a　novel　rigid-flexible　heterogeneous　material,　the　sandwich　structure　with　the　entangled　metallic　wire　mesh　(EMWM)　core　has　obvious　advantages　on　thermo-mechanical　performances　due　to　its　all-metallic　material　and　structure.　Of　particular　and　complexity　is　the　crosslinked　microstructure　of　EMWM　core,　leading　to　ambiguous　mechanical　behaviors　of　the　sandwich　structure　under　gradient　temperature　and　thermal　cycles.　In　the　work,　the　compressive　and　shear　properties　of　the　sandwich　structure　in　different　structure　directions　of　the　EMWM　core　were　investigated,　as　well　as　the　thermal　cycling　failure.　The　experimental　result　reveals　that　the　sandwich　structure　has　an　excellent　compression　performance　when　the　temperature　below　750　degrees　C.　With　the　temperature　increasing,　the　shear　performance　of　the　sandwich　structure　exhibits　a　trend　from　rise　to　decline.　Furthermore,　the　shear　property　of　the　sandwich　structure　in　the　transversal　direction　is　better　than　that　in　the　longitudinal　direction.　And,　the　effect　of　thermal　cycle　on　the　failure　behaviors　(including,　the　deformation　of　face-sheet　and　the　delamination　of　EMWM　core)　of　the　sandwich　structure　was　observed.　In　the　number　of　thermal　cycles　ranged　of　50-200,　there　are　few　declinations　of　the　compression　and　shear　performance　of　the　sandwich　structure.