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[期刊论文]

Shell penetration/free energy-driven crosstalk between intelligent DNA nanomachines for ultrasensitive detection of circulating tumor cells

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author:

Wu, Jingting (Wu, Jingting.) [1] | Liu, Ran (Liu, Ran.) [2] | Zheng, Xiaoqi (Zheng, Xiaoqi.) [3] | Unfold

Indexed by:

EI Scopus SCIE

Abstract:

Because of the extraordinary rarity, CTC detection remains a technological challenge. In this contribution, a stimuli-responsive intelligent DNA nanomachine system is demonstrated for ultrasensitive and specific CTC detection via a shell penetration/free energy-driven autonomous circuit. The responsive toeholds designed in linear probes are shielded by protective DNA self-assembled outer shell and hidden inwards from the attack of fuel strands, proposing an innovative concept different from conventional DNA hairpin-based catalytic reactions. DNA machines are very stable in the 'OFF' state, almost completely suppressing the background fluorescence. A linear trigger can permeate through outer shell and ignite the inner responsive toeholds, achieving an amplification fluorescent signal. CTC is specifically screened in a linear response range of three orders of magnitude with a detection limit of 2 cells/200 mu L with almost 100% accuracy, indicating 3.4 similar to 50-fold improvement in assay ability. (c) 2023 Published by Elsevier Ltd.

Keyword:

autonomous circuit Circulating tumor cells (CTCs) DNA nanomachine free energy-driven shell nanostructure Shell penetration Stimuli-responsive key homing Toehold-hidden core

Community:

  • [ 1 ] [Wu, Jingting]Fuzhou Univ, Canc Metastasis Alert & Prevent Ctr, Fujian Prov Key Lab Canc Metastasis Chemoprevent &, State Key Lab Photocatalysis Energy & Environm,Col, Fuzhou 350108, Peoples R China
  • [ 2 ] [Liu, Ran]Fuzhou Univ, Canc Metastasis Alert & Prevent Ctr, Fujian Prov Key Lab Canc Metastasis Chemoprevent &, State Key Lab Photocatalysis Energy & Environm,Col, Fuzhou 350108, Peoples R China
  • [ 3 ] [Zheng, Xiaoqi]Fuzhou Univ, Canc Metastasis Alert & Prevent Ctr, Fujian Prov Key Lab Canc Metastasis Chemoprevent &, State Key Lab Photocatalysis Energy & Environm,Col, Fuzhou 350108, Peoples R China
  • [ 4 ] [Chen, Linhuan]Fuzhou Univ, Canc Metastasis Alert & Prevent Ctr, Fujian Prov Key Lab Canc Metastasis Chemoprevent &, State Key Lab Photocatalysis Energy & Environm,Col, Fuzhou 350108, Peoples R China
  • [ 5 ] [Wu, Zai-Sheng]Fuzhou Univ, Canc Metastasis Alert & Prevent Ctr, Fujian Prov Key Lab Canc Metastasis Chemoprevent &, State Key Lab Photocatalysis Energy & Environm,Col, Fuzhou 350108, Peoples R China

Reprint 's Address:

  • [Wu, Zai-Sheng]Fuzhou Univ, Canc Metastasis Alert & Prevent Ctr, Fujian Prov Key Lab Canc Metastasis Chemoprevent &, State Key Lab Photocatalysis Energy & Environm,Col, Fuzhou 350108, Peoples R China;;

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Source :

NANO TODAY

ISSN: 1748-0132

Year: 2023

Volume: 49

1 3 . 2

JCR@2023

1 3 . 2 0 0

JCR@2023

ESI Discipline: PHYSICS;

ESI HC Threshold:30

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count:

30 Days PV: 2

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