Home>Results
Advanced Search
Indexed by:
Abstract:
Because of the extraordinary rarity, CTC detection remains a technological challenge. In this contribution, a stimuli-responsive intelligent DNA nanomachine system is demonstrated for ultrasensitive and specific CTC detection via a shell penetration/free energy-driven autonomous circuit. The responsive toeholds designed in linear probes are shielded by protective DNA self-assembled outer shell and hidden inwards from the attack of fuel strands, proposing an innovative concept different from conventional DNA hairpin-based catalytic reactions. DNA machines are very stable in the 'OFF' state, almost completely suppressing the background fluorescence. A linear trigger can permeate through outer shell and ignite the inner responsive toeholds, achieving an amplification fluorescent signal. CTC is specifically screened in a linear response range of three orders of magnitude with a detection limit of 2 cells/200 mu L with almost 100% accuracy, indicating 3.4 similar to 50-fold improvement in assay ability. (c) 2023 Published by Elsevier Ltd.
Keyword:
Reprint 's Address:
Email:
Version:
Source :
NANO TODAY
ISSN: 1748-0132
Year: 2023
Volume: 49
1 3 . 2
JCR@2023
1 3 . 2 0 0
JCR@2023
ESI Discipline: PHYSICS;
ESI HC Threshold:30
JCR Journal Grade:1
CAS Journal Grade:1
Affiliated Colleges:
查看更多>>操作日志
管理员 2024-10-25 12:12:03 追加
管理员 2024-09-25 11:05:06 追加
管理员 2024-07-25 14:23:12 追加
管理员 2024-06-25 13:58:04 追加