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学者姓名：吴再生
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Abstract ：
Via proposing an innovative assembly technique, we bundle cell-targeting aptamer-modified gold nanorods (AuNRs) with RCA product (RCA-p) tape into a reconfigurable nanocluster (ARGN) bomb for multimodal precision cancer therapy. Because each ARGN has 10 individual AuNRs, the short time of laser irradiation can make the temperature increase to 75 degrees C much higher than the lethal temperature of tumor cells, enabling the efficient photothermal therapy (PTT). Moreover, both siRNA-Plk1 (2820 per ARGN) and chemotherapeutic agents (15860 per ARGN) can be loaded into two specifically-designed containers in the internal cavity. Because the glomeroplasmatic structure enhances the resistance to enzymatic degradation, ARGN bomb can protect siRNAs from the digestion and avoid Dox leakage during in vivo circulation. Moreover, the spontaneous structural reorganization allows aptamers in the interior cavity move outward to the exterior surface, which magically offers the compensation of degraded aptamers and impair persistent in vivo cell targeting ability. The external stimuli (laser irradiation) promotes the release of chemotherapeutic agents and initiates the PTT/chemotherapy outcome, while endogenous stimuli (intracellular biomarkers) causes almost 100 % release of siRNA-Plk1 species and induces RNA interference therapy, completely inhibiting tumor growth without detectable off-target toxicity.
Keyword ：
Bundling gold nanorods into a reconfigurable nanocluster Bundling gold nanorods into a reconfigurable nanocluster Explosive cluster bomb for precise combination chemotherapy Explosive cluster bomb for precise combination chemotherapy Multimodal synergetic cancer therapy Multimodal synergetic cancer therapy RCA-Based adhesive tape RCA-Based adhesive tape
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| GB/T 7714 | Gao, Qian , Wang, Weijun , Sun, Shujuan et al. Bundling gold nanorods with RCA-produced DNA tape into an intelligently reconfigurable nanocluster bomb for multimodal precision cancer therapy [J]. | MATERIALS TODAY BIO , 2025 , 32 . |
| MLA | Gao, Qian et al. "Bundling gold nanorods with RCA-produced DNA tape into an intelligently reconfigurable nanocluster bomb for multimodal precision cancer therapy" . | MATERIALS TODAY BIO 32 (2025) . |
| APA | Gao, Qian , Wang, Weijun , Sun, Shujuan , Yang, Ya , Mao, Kaili , Yang, Yuxi et al. Bundling gold nanorods with RCA-produced DNA tape into an intelligently reconfigurable nanocluster bomb for multimodal precision cancer therapy . | MATERIALS TODAY BIO , 2025 , 32 . |
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The abnormal expression of miRNA-21 is closely related to many cancers, and its sensitive detection plays an important role in the diagnosis and treatment of cancers. In the report, we designed a non-enzymatic amplification sensing system based on the catalytic hairpin assembly (CHA) and palindrome-based hybridization chain reaction (PHCR) technique for the detection and imaging of miRNA in living cells. Based on PHCR technology, two ingeniously designed palindrome-contained fluorescently labeled hairpin probes are sequentially opened upon the stimulation of short oligonucleotide triggers, promoting the autonomous assembly of cross-linked network-like structures (CNSs) and generating fluorescence resonance energy transfer (FRET) signal. Moreover, the PHCR technique can be combined with CHA technology to sufficiently improve amplification efficiency and signal output. By utilizing the CHA-PHCR sensing system, one miRNA-21 activates many triggers through CHA process and in turn initiates the assembly of CNSs by PHCR reaction, efficiently amplifying the FRET signal output. As such, the sensing system can detect target miRNAs down to 10 pm with high detection specificity. Moreover, the CNS exhibits the enhanced intracellular stability, enabling the living cell imaging of miRNA-21. The CHA-PHCR sensing system can also screen the expression level of miRNA-21 in different living cells and differentiate cancer cells from healthy cells, which is consistent with the gold-standard PCR method. © 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
Keyword ：
CHA-PHCR combination technique CHA-PHCR combination technique Cross-linked network structures (CNSs) Cross-linked network structures (CNSs) Live-cell imaging Live-cell imaging MiRNA detection MiRNA detection Palindromic hairpin probe Palindromic hairpin probe
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| GB/T 7714 | Wu, Z.-S. , Li, C. . Live-Cell Imaging of miRNAs with the Combination of CHA and HCR Techniques [J]. | Methods in molecular biology (Clifton, N.J.) , 2025 , 2875 : 177-187 . |
| MLA | Wu, Z.-S. et al. "Live-Cell Imaging of miRNAs with the Combination of CHA and HCR Techniques" . | Methods in molecular biology (Clifton, N.J.) 2875 (2025) : 177-187 . |
| APA | Wu, Z.-S. , Li, C. . Live-Cell Imaging of miRNAs with the Combination of CHA and HCR Techniques . | Methods in molecular biology (Clifton, N.J.) , 2025 , 2875 , 177-187 . |
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An RCA product is a promising scaffold for the construction of DNA nanostructures, but so far, there is no RCA scaffold-based dynamic reconfigurable nanorobot for biological applications. In this contribution, we develop an intracellular stimuli-responsive reconfigurable coiled DNA nanosnake (N-Snake) by using incomplete aptamer-functionalized (A) DNA tetrahedrons (T) to fold a long tandemly repetitive DNA strand synthesized by rolling circle amplification reaction (R) with the help of palindromic fragment (P). A DNA-assembled product, ARTP, including spiked aptamers, can retain the structural integrity even if exposed to fetal bovine serum (FBS) for 24 h and displays substantially enhanced target molecule-dependent cellular internalization efficiency. ARTP contains tetrahedral containers and linear containers, so that there are 500 doxorubicins (DOXs) and 12.5 siRNAs per ARTP. Moreover, ARTP can precisely transport anticancer drugs to cancerous sites and controllably release via the structural reconfiguration upon intracellular stimuli, almost 100% inhibiting tumor growth without detectable systemic toxicity owing to the synergistic RNAi-/Chemotherapy. Apparently, coiled N-snake, DOX/siPlk1-loaded ARTP, can specifically enter tumor cells, uncoil upon intracellular stimuli, and attack the cells from the inside, exerting precise cancer therapy.
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| GB/T 7714 | Li, Congcong , Lin, Wenqing , Wang, Weijun et al. Folding an RCA Scaffold into an Intelligent Coiled Nanosnake for Precise/Synergistic RNAi-/Chemotherapy of Cancer [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (2) : 1107-1116 . |
| MLA | Li, Congcong et al. "Folding an RCA Scaffold into an Intelligent Coiled Nanosnake for Precise/Synergistic RNAi-/Chemotherapy of Cancer" . | ANALYTICAL CHEMISTRY 97 . 2 (2025) : 1107-1116 . |
| APA | Li, Congcong , Lin, Wenqing , Wang, Weijun , Wu, Jingting , Luo, Shasha , Chen, Linhuan et al. Folding an RCA Scaffold into an Intelligent Coiled Nanosnake for Precise/Synergistic RNAi-/Chemotherapy of Cancer . | ANALYTICAL CHEMISTRY , 2025 , 97 (2) , 1107-1116 . |
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While engineered DNA nanoframeworks have been extensively exploited for delivery of diagnostic and therapeutic regents, DNA tiling-based DNA frameworks amenable to applications in living systems lag much behind. In this contribution, by developing a Y-shaped backbone-based DNA tiling technique, we assemble Y-shaped backbone-rigidified supersized DNA tetrahedrons (RDT) with 100% efficiency for precisely targeted tumor therapy. RDT displays unparalleled rigidness and unmatched resistance to nuclease degradation so that it almost does not deform under the force exerted by the atomic force microscopy tip, and the residual amount is not less than 90% upon incubating in biological media for 24 h, displaying at least 11.6 times enhanced degradation resistance. Without any targeting ligand, RDT enters the cancer cell in a targeted manner, and internalization specificity is up to 15.8. Moreover, 77% of RDT objects remain intact within living cells for 14 h. The drug loading content of RDT is improved by 4-8 times, and RDT almost 100% eliminates the unintended drug leakage in a stimulated physiological medium. Once systemically administrated into HeLa tumor-bearing mouse models, doxorubicin-loaded RDTs preferentially accumulate in tumor sites and efficiently suppress tumor growth without detectable off-target toxicity. The Y-DNA tiling technique offers invaluable insights into the development of structural DNA nanotechnology for precise medicine.
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| GB/T 7714 | Wang, Weijun , Lin, Mengling , Chen, Yan-Ru et al. Y-Shaped Backbone-Rigidified DNA Tiles for the Construction of Supersized Nondeformable Tetrahedrons for Precise Cancer Therapies [J]. | ANALYTICAL CHEMISTRY , 2024 , 96 (4) : 1488-1497 . |
| MLA | Wang, Weijun et al. "Y-Shaped Backbone-Rigidified DNA Tiles for the Construction of Supersized Nondeformable Tetrahedrons for Precise Cancer Therapies" . | ANALYTICAL CHEMISTRY 96 . 4 (2024) : 1488-1497 . |
| APA | Wang, Weijun , Lin, Mengling , Chen, Yan-Ru , Wang, Wenqing , Lv, Jinrui , Chen, Yaxin et al. Y-Shaped Backbone-Rigidified DNA Tiles for the Construction of Supersized Nondeformable Tetrahedrons for Precise Cancer Therapies . | ANALYTICAL CHEMISTRY , 2024 , 96 (4) , 1488-1497 . |
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Although DNA probes have attracted increasing interest for precise tumor cell identification by imaging intracellular biomarkers, the requirement of commercial transfection reagents, limited targeting ligands, and/or non-biocompatible inorganic nanostructures has hampered the clinic translation. To circumvent these shortcomings, a reconfigurable ES-NC (Na+-dependent DNAzyme (E)-based substrate (S) cleavage core/shell DNA nanocluster (NC)) entirely from DNA strands is assembled for precise imaging of cancerous cells in a successive dual-stimuli-responsive manner. This nanoprobe is composed of a strung DNA tetrahedral satellites-based protective (DTP) shell, parallelly aligned target-responsive sensing (PTS) interlayer, and hydrophobic cholesterol-packed innermost layer (HCI core). Tetrahedral axial rotation-activated reconfiguration of DTP shell promotes the exposure of interior hydrophobic moieties, enabling cholesterol-mediated cellular internalization without auxiliary elements. Within cells, over-expressed glutathione triggers the disassembly of the DTP protective shell (first stimulus), facilitating target-stimulated signal transduction/amplification process (second stimuli). Target miRNA-21 is detected down to 10.6 fM without interference from coexisting miRNAs. Compared with transfection reagent-mediated counterpart, ES-NC displays a higher imaging ability, resists nuclease degradation, and has no detectable damage to healthy cells. The blind test demonstrates that the ES-NC is suitable for the identification of cancerous cells from healthy cells, indicating a promising tool for early diagnosis and prediction of cancer. A reconfigurable core/shell DNAzyme-based ES-NC nanoprobe is demonstrated for the specific identification of cancerous cells. Axial rotation of the tetrahedral shell turns interior cholester moieties inside out and makes ES-NC grow a wiggling tentacle, contributing to cellular internalization. The disassembly of the protective shell by endogenous stimuli exposes the target miRNA binding site and catalytic core, activating the signal transduction/amplification process for cell imaging. image
Keyword ：
axial rotation-based structural reconfiguration axial rotation-based structural reconfiguration ES-NC nanoprobe made entirely of DNA strands ES-NC nanoprobe made entirely of DNA strands hydrophobicity-mediated assembly hydrophobicity-mediated assembly precise tumor cell identification precise tumor cell identification successive dual stimuli-responsive intracellular signaling successive dual stimuli-responsive intracellular signaling
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| GB/T 7714 | Pan, Wenhao , Niu, Huimin , Luo, Shasha et al. Intelligent Reconfiguration-Promoted Cellular Internalization of Core-Shell DNA Nanoprobe Equipped with Successive Dual Stimuli-Responsive Protective Satellites for Amplification Fluorescence Imaging of Tumor Cells [J]. | SMALL , 2024 , 20 (28) . |
| MLA | Pan, Wenhao et al. "Intelligent Reconfiguration-Promoted Cellular Internalization of Core-Shell DNA Nanoprobe Equipped with Successive Dual Stimuli-Responsive Protective Satellites for Amplification Fluorescence Imaging of Tumor Cells" . | SMALL 20 . 28 (2024) . |
| APA | Pan, Wenhao , Niu, Huimin , Luo, Shasha , Chen, Linhuan , Wu, Zai-Sheng . Intelligent Reconfiguration-Promoted Cellular Internalization of Core-Shell DNA Nanoprobe Equipped with Successive Dual Stimuli-Responsive Protective Satellites for Amplification Fluorescence Imaging of Tumor Cells . | SMALL , 2024 , 20 (28) . |
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A major impediment to the clinical translation of DNA tiling nanostructures is a technical bottleneck for the programmable assembly of DNA architectures with well-defined local geometry due to the inability to achieve both sufficient structural rigidity and a large framework. In this work, a Y-backbone was inserted into each face to construct a superlarge, sufficiently rigidified tetrahedral DNA nanostructure (called RDT) with extremely high efficiency. In RDT, the spatial size increased by 6.86-fold, and the structural rigidity was enhanced at least 4-fold, contributing to an similar to 350-fold improvement in the resistance to nucleolytic degradation even without a protective coating. RDT can be mounted onto an artificial lipid-bilayer membrane with molecular-level precision and well-defined spatial orientation that can be validated using the fluorescence resonance energy transfer (FRET) assay. The spatial orientation of Y-shaped backbone-rigidified RDT is unachievable for conventional DNA polyhedrons and ensures a high level of precision in the geometric positioning of diverse biomolecules with an approximately homogeneous environment. In tests of RDT, surface-confined horseradish peroxidase (HRP) exhibited nearly 100% catalytic activity and targeting aptamer-immobilized gold nanoparticles showed 5.3-fold enhanced cellular internalization. Significantly, RDT exhibited a 27.5-fold enhanced structural stability in a bodily environment and did not induce detectable systemic toxicity.
Keyword ：
assembly ofsuperlarge DNA tetrahedron assembly ofsuperlarge DNA tetrahedron enhanced nuclease-resistant superlarge DNAnanoframework enhanced nuclease-resistant superlarge DNAnanoframework hollow framework-guided high-precision organizationof biomolecules hollow framework-guided high-precision organizationof biomolecules spatially addressable DNA tilingarchitecture spatially addressable DNA tilingarchitecture Y-shaped backbone-rigidified structure Y-shaped backbone-rigidified structure
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| GB/T 7714 | Wang, Weijun , Wang, Wenqing , Chen, Yaxin et al. Superlarge, Rigidified DNA Tetrahedron with a Y-Shaped Backbone for Organizing Biomolecules Spatially and Maintaining Their Full Bioactivity [J]. | ACS NANO , 2024 , 18 (28) : 18257-18281 . |
| MLA | Wang, Weijun et al. "Superlarge, Rigidified DNA Tetrahedron with a Y-Shaped Backbone for Organizing Biomolecules Spatially and Maintaining Their Full Bioactivity" . | ACS NANO 18 . 28 (2024) : 18257-18281 . |
| APA | Wang, Weijun , Wang, Wenqing , Chen, Yaxin , Lin, Mengling , Chen, Yan-Ru , Zeng, Ruijin et al. Superlarge, Rigidified DNA Tetrahedron with a Y-Shaped Backbone for Organizing Biomolecules Spatially and Maintaining Their Full Bioactivity . | ACS NANO , 2024 , 18 (28) , 18257-18281 . |
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While the intracellular imaging of miRNA biomarkers is of significant importance for the diagnosis and treatment of human cancers, DNA assembled nanoprobe has recently attracted considerable attention for imaging intracellular biomolecules. However, the complex construction process, intrinsic vulnerability to nuclease degradation and the limited signal transduction efficiency hamper its widespread application. In this contribution, based on persistent autonomous molecular motion of DNAzyme walker along a nano-substrate track, a DNA nanosphere probe (PNLD) is developed for the sensitive intracellular miR-21 imaging. Specifically, DNA nanosphere (called PN, single-molecule nano-track) is assembled from only one palindromic substrate, into which the locking strand-silenced DNAzymes (LD) are installed in a controlled manner. PNLD (made of PN and LD) can protect all DNA components against nuclease attack and maintain its structural integrity in serum solution over 24 h. Upon the activation by target miRNA, DNAzyme walker can move on the substrate scattered within PNLD (or on the surface) and between different PNLD objects and cleave many DNA substrates, generating an amplified signal. As a result, miR-21 can be detected down to 6.83 pM without the detectable interference from co-existing nontarget miRNAs. Moreover, PNLD system can accurately screen the different expression levels of miR-21 within the same type of cells and different types of cells, which is consistent with gold standard polymerase chain reaction (PCR) assay. Via changing the target recognition sequence, the PNLD system can be suitable for the intracellular imaging of miR-155, exhibiting the desirable universality. In addition, the DNAzyme walker-based PNLD system can be used to distinguish cancer cells from healthy cells, implying the potential application in cancer diagnosis and prognosis.
Keyword ：
Cell imaging Cell imaging DNA walker DNA walker Fluorescence Fluorescence miRNA detection miRNA detection Single-molecule track Single-molecule track
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| GB/T 7714 | Pan, Wenhao , Chen, Linhuan , Zhu, Shidan et al. Persistent autonomous molecular motion of DNA walker along a single-molecule nano-track for intracellular MicroRNA imaging [J]. | TALANTA , 2024 , 280 . |
| MLA | Pan, Wenhao et al. "Persistent autonomous molecular motion of DNA walker along a single-molecule nano-track for intracellular MicroRNA imaging" . | TALANTA 280 (2024) . |
| APA | Pan, Wenhao , Chen, Linhuan , Zhu, Shidan , Li, Dongyu , Shen, Zhifa , Wu, Zai-Sheng . Persistent autonomous molecular motion of DNA walker along a single-molecule nano-track for intracellular MicroRNA imaging . | TALANTA , 2024 , 280 . |
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Construction of a simple, reconfigurable, and stimuli-responsive DNA nanocarrier remains a technical challenge. In this contribution, by designing three palindromic fragments, a simplest four-sticky end-contained 3D structural unit (PS-unit) made of two same DNA components is proposed. Via regulating the rotation angle of central longitudinal axis of PS-unit, the oriented assembly of one-component spherical architecture is accomplished with high efficiency. Introduction of an aptamer and sticky tail warehouse into one component creates a size-change-reversible targeted siRNA delivery nanovehicle. Volume swelling of 20 nm allows one carrier to load 1987 siPLK1s. Once entering cancer cells and responding to glutathione (GSH) stimuli, siPLK1s are almost 100% released and original size of nanovehicle is restored, inhibiting the expression of PLK1 protein and substantially suppressing tumor growth (superior to commercial transfection agents) in tumor-bearing mice without systemic toxicity. A simple, reconfigurable, and stimuli-responsive DNA nanocarrier is developed for targeted siRNA delivery by using one-component. Once entering cancer cells and responding to GSH stimuli, siPLK1s are almost 100% released and original size of nanovehicle is restored, inhibiting the expression of PLK1 protein and achieving tumor growth suppression (superior to commercial transfection agents) in tumor-bearing mice without systemic toxicity. image
Keyword ：
DNA nanocarrier DNA nanocarrier gene silencing gene silencing stimuli-responsive drug release stimuli-responsive drug release structural unit made of only one palindromic strand structural unit made of only one palindromic strand tumor inhibition tumor inhibition
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| GB/T 7714 | Wu, Jingting , Zheng, Xiaoqi , Lin, Wenqing et al. Persistent Targeting DNA Nanocarrier Made of 3D Structural Unit Assembled from Only One Basic Multi-Palindromic Oligonucleotide for Precise Gene Cancer Therapy [J]. | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (11) . |
| MLA | Wu, Jingting et al. "Persistent Targeting DNA Nanocarrier Made of 3D Structural Unit Assembled from Only One Basic Multi-Palindromic Oligonucleotide for Precise Gene Cancer Therapy" . | ADVANCED HEALTHCARE MATERIALS 13 . 11 (2024) . |
| APA | Wu, Jingting , Zheng, Xiaoqi , Lin, Wenqing , Chen, Linhuan , Wu, Zai-Sheng . Persistent Targeting DNA Nanocarrier Made of 3D Structural Unit Assembled from Only One Basic Multi-Palindromic Oligonucleotide for Precise Gene Cancer Therapy . | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (11) . |
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DNA not only plays a vital role in nature as fundamental hereditary material for storing genetic material, but also serves as well-defined functional material, for example, building blocks for the assembly of nanoscale bioarchitectures by Watson-Crick base-pairing interaction. With the development of molecular biology, biotechnology and nanoscience, structural DNA nanotechnology has achieved numerous advances, contributing to the construction of various DNA nanostructures ranging from discrete objects to one dimensional (1D), two dimensional (2D), and three dimensional (3D) architectures. Among them, DNA tetrahedral nanoarchitecture is intensively studied because of simple 3D structure, easy design and unique properties, such as high rigidity, desirable biostability and efficient cellular uptake without auxiliary species. This review summarizes the research progress in the assembly of DNA tetrahedral objects and outlines the applications in biosensing, drug delivery and targeted therapy. Moreover, the dependence of biological activity of biomolecules on DNA tetrahedronmediated spatially-controlled arrangement and great potential applications are discussed. In addition, the challenges in the design and clinic applications of DNA tetrahedron-based platforms are described, the perspectives towards biomedical applications are foreseen, and our understandings on further studies of DNA tetrahedron are provided, aiming to motivate the development of DNA nanotechnology and interdisciplinary research.
Keyword ：
Biomarker detection Biomarker detection cancer treatment cancer treatment DNA nanotechnology DNA nanotechnology DNA tetrahedron DNA tetrahedron Drug delivery Drug delivery Oriented arrangement Oriented arrangement
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| GB/T 7714 | Wang, Weijun , Lin, Mengling , Wang, Wenqing et al. DNA tetrahedral nanostructures for the biomedical application and spatial orientation of biomolecules [J]. | BIOACTIVE MATERIALS , 2024 , 33 : 279-310 . |
| MLA | Wang, Weijun et al. "DNA tetrahedral nanostructures for the biomedical application and spatial orientation of biomolecules" . | BIOACTIVE MATERIALS 33 (2024) : 279-310 . |
| APA | Wang, Weijun , Lin, Mengling , Wang, Wenqing , Shen, Zhifa , Wu, Zai-Sheng . DNA tetrahedral nanostructures for the biomedical application and spatial orientation of biomolecules . | BIOACTIVE MATERIALS , 2024 , 33 , 279-310 . |
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Detection of intracellular miRNAs, especially sensitive imaging of in vivo miRNAs, is vital to the precise prediction and timely prevention of tumorgenesis but remains a technical challenge in terms of nuclease resistance and signal amplification. Here, we demonstrate a gold nanoparticle-based spherical nucleic acid-mediated spatial matching-guided nonenzymatic DNA circuit (SSDC) for efficient screening of intracellular miRNAs and, in turn, finding cancerous tissues in living organisms before the appearance of clinical symptoms. Due to the substantially enhanced nuclease resistance, the false positive signal is avoided even in a complex biological medium. Target miRNA can straighten out the hairpin DNA probe to be linear, allowing the probe to penetrate into the internal region of a core/shell DNA-functionalized signal nanoampfilier and initiate a strand displacement reaction, generating an amplified fluorescence signal. The detection limit is as low as 17 pM, and miRNA imaging is in good accordance with the gold standard polymerase chain reaction method. The ability to image intracellular miRNAs is substantially superior to that of conventional fluorescence in situ hybridization techniques, making in vivo SSDC-based imaging competent for the precise prediction of tumorigenesis. By intratumoral chemotherapy guided by SSDC-based imaging, tumorigenesis and progression are efficiently controlled before the onset of clinical symptoms.
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| GB/T 7714 | Wang, Weijun , Li, Congcong , Luo, Shasha et al. Spherical Nucleic Acid-Mediated Spatial Matching-Guided Nonenzymatic DNA Circuits for the Prediction and Prevention of Malignant Tumor Invasion [J]. | ANALYTICAL CHEMISTRY , 2024 , 96 (18) : 7091-7100 . |
| MLA | Wang, Weijun et al. "Spherical Nucleic Acid-Mediated Spatial Matching-Guided Nonenzymatic DNA Circuits for the Prediction and Prevention of Malignant Tumor Invasion" . | ANALYTICAL CHEMISTRY 96 . 18 (2024) : 7091-7100 . |
| APA | Wang, Weijun , Li, Congcong , Luo, Shasha , Wu, Zai-Sheng . Spherical Nucleic Acid-Mediated Spatial Matching-Guided Nonenzymatic DNA Circuits for the Prediction and Prevention of Malignant Tumor Invasion . | ANALYTICAL CHEMISTRY , 2024 , 96 (18) , 7091-7100 . |
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