In　this　study,　Cu　was　loaded　on　the　surface　of　Ni-MOF　by　impregnation,　and　significantly　improved　the　catalytic　activity　on　lignin　and　its　derivatives.　The　characterization　showed　that　the　non-noble　bimetallic　catalyst　owned　good　dispersion,　rich　acid　sites　and　stable　structure　was　successfully　synthesized.　The　introduced　Cu　reduced　the　reduction　temperature　of　Ni,　increased　the　acidity　of　the　catalyst,　and　thus　improved　the　catalytic　performance　and　product　selectivity　of　the　catalyst.　Under　the　mild　conditions　(120　°C),　the　conversion　percentage　of　BPE　was　as　high　as　89.6　%　using　isopropyl　alcohol　as　the　hydrogen　source.　When　the　reaction　temperature　was　260　°C,　the　depolymerization　percentage　of　corn　cob　lignin　was　81.12　%,　and　the　yield　of　phenol　monomer　could　reach　11.46　wt.　%.　This　work　may　provide　an　effective　strategy　for　the　preparation　of　efficient　bimetallic　catalysts　for　lignin　hydrogenolysis.　©　2023　Elsevier　B.V.