Enhancing Catalytic Activity of a Nickel Single Atom Enzyme by Polynary Heteroatom Doping for Ferroptosis-Based Tumor Therapy - Details

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Abstract：

As　a　rising　generation　of　nanozymes,　single　atom　enzymes　show　significant　promise　for　cancer　therapy,　due　to　their　maximum　atom　utilization　efficiency　and　well-defined　electronic　structures.　However,　it　remains　a　tremendous　challenge　to　precisely　produce　a　heteroatom-doped　single　atom　enzyme　with　an　expected　coordination　environment.　Herein,　we　develop　an　anion　exchange　strategy　for　precisely　controlled　production　of　an　edge-rich　sulfur　(S)-　and　nitrogen　(N)-decorated　nickel　single　atom　enzyme　(S-N/Ni　PSAE).　In　particular,　sulfurized　S-N/Ni　PSAE　exhibits　stronger　peroxidase-like　and　glutathione　oxidase-like　activities　than　the　nitrogen-monodoped　nickel　single　atom　enzyme,　which　is　attributed　to　the　vacancies　and　defective　sites　of　sulfurized　nitrogen　atoms.　Moreover,　both　in　vitro　and　in　vivo　results　demonstrate　that,　compared　with　nitrogen-monodoped　N/Ni　PSAE,　sulfurized　S-N/Ni　PSAE　more　effectively　triggers　ferroptosis　of　tumor　cells　via　inactivating　glutathione　peroxidase　4　and　inducing　lipid　peroxidation.　This　study　highlights　the　enhanced　catalytic　efficacy　of　a　polynary　heteroatom-doped　single　atom　enzyme　for　ferroptosis-based　cancer　therapy.　©　2023　American　Chemical　Society.

Keyword：

ferroptosis heteroatom doping lipid peroxidation single atom enzyme tumor therapy

Community：

[ 1 ] [Zhu, Y.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Zhu, Y.]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine, Faculty of Engineering, National University of Singapore, Singapore, 117597, Singapore
[ 3 ] [Wang, W.]First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, Hefei, 230026, China
[ 4 ] [Gong, P.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Zhao, Y.]First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, Hefei, 230026, China
[ 6 ] [Pan, Y.]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine, Faculty of Engineering, National University of Singapore, Singapore, 117597, Singapore
[ 7 ] [Zou, J.]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine, Faculty of Engineering, National University of Singapore, Singapore, 117597, Singapore
[ 8 ] [Ao, R.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 9 ] [Wang, J.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 10 ] [Cai, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 11 ] [Huang, H.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 12 ] [Yu, M.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 13 ] [Wang, H.]Experimental Center of Engineering and Material Science, University of Science and Technology of China, Hefei, 230026, China
[ 14 ] [Lin, L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 15 ] [Chen, X.]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine, Faculty of Engineering, National University of Singapore, Singapore, 117597, Singapore
[ 16 ] [Wu, Y.]First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, Hefei, 230026, China
[ 17 ] [Wu, Y.]Dalian National Laboratory for Clean Energy, Dalian, 116023, China

Reprint 's Address：

[Lin, L.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, China;;[Chen, X.]Departments of Diagnostic Radiology, Singapore;;[Wu, Y.]First Affiliated Hospital of USTC, Anhui, China

Email：

lisen.lin@fzu.edu.cn |
chen.shawn@nus.edu.sg |
yuenwu@ustc.edu.cn

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Source ：

ACS Nano

ISSN： 1936-0851

Year： 2023

Issue： 3

Volume： 17

Page： 3064-3076

1 5 . 8

JCR@2023

1 5 . 8 0 0

JCR@2023

ESI HC Threshold：49

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

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