Ferroptosis　is　an　oxidative　damage-related,　iron-dependent　regulated　cell　death　with　intracellular　lipid　peroxide　accumulation,　which　is　associated　with　many　physiological　and　pathological　processes.　It　exhibits　unique　features　that　are　morphologically,　biochemically,　and　immunologically　distinct　from　other　regulated　cell　death　forms.　Ferroptosis　is　regulated　by　iron　metabolism,　lipid　metabolism,　anti-oxidant　defense　systems,　as　well　as　various　signal　pathways.　Hypoxia,　which　is　found　in　a　group　of　physiological　and　pathological　conditions,　can　affect　multiple　cellular　functions　by　activation　of　the　hypoxia-inducible　factor　(HIF)　signaling　and　other　mechanisms.　Emerging　evidence　demonstrated　that　hypoxia　regulates　ferroptosis　in　certain　cell　types　and　conditions.　In　this　review,　we　summarize　the　basic　mechanisms　and　regulations　of　ferroptosis　and　hypoxia,　as　well　as　the　regulation　of　ferroptosis　by　hypoxia　in　physiological　and　pathological　conditions,　which　may　contribute　to　the　numerous　diseases　therapies.