A Sulfur-Bridging Sulfonate-Modified Zinc(II) Phthalocyanine Nanoliposome Possessing Hybrid Type I and Type II Photoreactions with Efficient Photodynamic Anticancer Effects - Details

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Abstract：

Phthalocyanines　are　potentially　promising　photosensitizers　(PSs)　for　photodynamic　therapy　(PDT),　but　the　inherent　defects　such　as　aggregation-caused　quenching　effects　and　non-specific　toxicity　severely　hinder　their　further　application　in　PDT.　Herein,　we　synthesized　two　zinc(II)　phthalocyanines　(PcSA　and　PcOA)　monosubstituted　with　a　sulphonate　group　in　the　alpha　position　with　“O　bridge”　and　“S　bridge”　as　bonds　and　prepared　a　liposomal　nanophotosensitizer　(PcSA@Lip)　by　thin-film　hydration　method　to　regulate　the　aggregation　of　PcSA　in　the　aqueous　solution　and　enhance　its　tumor　targeting　ability.　PcSA@Lip　exhibited　highly　efficient　production　of　superoxide　radical　(O2∙−)　and　singlet　oxygen　(1O2)　in　water　under　light　irradiation,　which　were　2.6-fold　and　15.4-fold　higher　than　those　of　free　PcSA,　respectively.　Furthermore,　PcSA@Lip　was　able　to　accumulate　selectively　in　tumors　after　intravenous　injection　with　the　fluorescence　intensity　ratio　of　tumors　to　livers　was　4.1:1.　The　significant　tumor　inhibition　effects　resulted　in　a　98%　tumor　inhibition　rate　after　PcSA@Lip　was　injected　intravenously　at　an　ultra-low　PcSA@Lip　dose　(0.8　nmol　g−1　PcSA)　and　light　dose　(30　J　cm−2).　Therefore,　the　liposomal　PcSA@Lip　is　a　prospective　nanophotosensitizer　possessing　hybrid　type　I　and　type　II　photoreactions　with　efficient　photodynamic　anticancer　effects.　©　2023　by　the　authors.

Keyword：

anticancer fluorescence imaging liposome photodynamic therapy phthalocyanine

Community：

[ 1 ] [Chen, Z.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Zhao, Y.-Y.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Li, L.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Li, Z.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Fu, S.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 6 ] [Xu, Y.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 7 ] [Zheng, B.-Y.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 8 ] [Ke, M.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 9 ] [Li, X.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 10 ] [Huang, J.-D.]State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

[Li, X.]State Key Laboratory of Photocatalysis on Energy and Environment, China;;[Huang, J.-D.]State Key Laboratory of Photocatalysis on Energy and Environment, China

Email：

xingshuli@fzu.edu.cn |
jdhuang@fzu.edu.cn

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Related Keywords：

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Source ：

Molecules

ISSN： 1420-3049

Year： 2023

Issue： 5

Volume： 28

4 . 2

JCR@2023

4 . 2 0 0

JCR@2023

ESI HC Threshold：39

JCR Journal Grade：2

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 3

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

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