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author：

Fang, Z. (Fang, Z..) [1] | Lv, Y. (Lv, Y..) [2] | Zhang, H. (Zhang, H..) [3] | He, Y. (He, Y..) [4] | Gao, H. (Gao, H..) [5] | Chen, C. (Chen, C..) [6] | Wang, D. (Wang, D..) [7] | Chen, P. (Chen, P..) [8] | Tang, S. (Tang, S..) [9] | Li, J. (Li, J..) [10] | Qiu, Z. (Qiu, Z..) [11] | Shi, X. (Shi, X..) [12] | Chen, L. (Chen, L..) [13] | Yang, J. (Yang, J..) [14] | Chen, X. (Chen, X..) [15]

Indexed by：

Scopus

Abstract：

Persistent　oxidative　stress　and　recurring　waves　of　inflammation　with　excessive　reactive　oxygen　species　(ROS)　and　free　radical　accumulation　could　be　generated　by　radiation.　Exposure　to　radiation　in　combination　with　physical　injuries　such　as　wound　trauma　would　produce　a　more　harmful　set　of　medical　complications,　which　was　known　as　radiation　combined　with　skin　wounds　(RCSWs).　However,　little　attention　has　been　given　to　RCSW　research　despite　the　unsatisfactory　therapeutic　outcomes.　In　this　study,　a　dual-nanoagent-loaded　multifunctional　hydrogel　was　fabricated　to　ameliorate　the　pathological　microenvironment　associated　with　RCSWs.　The　injectable,　adhesive,　and　self-healing　hydrogel　was　prepared　by　crosslinking　carbohydrazide-modified　gelatin　(Gel-CDH)　and　oxidized　hyaluronic　acid　(OHA)　through　the　Schiff-base　reaction　under　mild　condition.　Polydopamine　nanoparticles　(PDA-NPs)　and　mesenchymal　stem　cell-secreted　small　extracellular　vesicles　(MSC-sEV)　were　loaded　to　relieve　radiation-produced　tissue　inflammation　and　oxidation　impairment　and　enhance　cell　vitality　and　angiogenesis　individually　or　jointly.　The　proposed　PDA-NPs@MSC-sEV　hydrogel　enhanced　cell　vitality,　as　shown　by　cell　proliferation,　migration,　colony　formation,　and　cell　cycle　and　apoptosis　assays　in　vitro,　and　promoted　reepithelization　by　attenuating　microenvironment　pathology　in　vivo.　Notably,　a　gene　set　enrichment　analysis　of　proteomic　data　revealed　significant　enrichment　with　adipogenic　and　hypoxic　pathways,　which　play　prominent　roles　in　wound　repair.　Specifically,　target　genes　were　predicted　based　on　differential　transcription　factor　expression.　The　results　suggested　that　MSC-sEV-　and　PDA-NP-loaded　multifunctional　hydrogels　may　be　promising　nanotherapies　for　RCSWs.　Statement　of　significance:　The　small　extracellular　vesicle　(sEV)　has　distinct　advantages　compared　with　MSCs,　and　polydopamine　nanoparticles　(PDA-NPs),　known　as　the　biological　materials　with　good　cell　affinity　and　histocompatibility　which　have　been　reported　to　scavenge　ROS　free　radicals.　In　this　study,　an　adhesive,　injectable,　self-healing,　antibacterial,　ROS　scavenging　and　amelioration　of　the　radiation　related　microenvironment　hydrogel　encapsulating　nanoscale　particles　of　MSC-sEV　and　PDA-NPs　(PDA-NPs@MSC-sEV　hydrogel)　was　synthesized　for　promoting　radiation　combined　with　skin　wounds　(RCSWs).　GSEA　analysis　profiled　by　proteomics　data　revealed　significant　enrichments　in　the　regulations　of　adipogenic　and　hypoxic　pathways　with　this　multi-functional　hydrogel.　This　is　the　first　report　of　combining　this　two　promising　nanoscale　agents　for　the　special　skin　wounds　associated　with　radiation.　©　2023　Acta　Materialia　Inc.

Keyword：

Extracellular vesicles Hydrogel Nanomedicine Polydopamine nanoparticles Radiation combined with skin wounds

Community：

  • [ 1 ] [Fang, Z.]Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, China
  • [ 2 ] [Fang, Z.]Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, 350001, China
  • [ 3 ] [Fang, Z.]Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University350001, China
  • [ 4 ] [Fang, Z.]Department of Stem Cell Research Institute, Fujian Medical University, Fuzhou, 350004, China
  • [ 5 ] [Lv, Y.]College of Biological Science and Engineering, Fuzhou University, No. 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 6 ] [Lv, Y.]Fujian Key Laboratory of Medical Instrument and Pharmaceutical Technology, Fuzhou University, No. 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 7 ] [Zhang, H.]Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, China
  • [ 8 ] [Zhang, H.]Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, 350001, China
  • [ 9 ] [Zhang, H.]Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University350001, China
  • [ 10 ] [Zhang, H.]Department of Stem Cell Research Institute, Fujian Medical University, Fuzhou, 350004, China
  • [ 11 ] [He, Y.]College of Biological Science and Engineering, Fuzhou University, No. 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 12 ] [He, Y.]Fujian Key Laboratory of Medical Instrument and Pharmaceutical Technology, Fuzhou University, No. 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 13 ] [Gao, H.]Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, China
  • [ 14 ] [Gao, H.]Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, 350001, China
  • [ 15 ] [Gao, H.]Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University350001, China
  • [ 16 ] [Gao, H.]Department of Stem Cell Research Institute, Fujian Medical University, Fuzhou, 350004, China
  • [ 17 ] [Chen, C.]Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, China
  • [ 18 ] [Chen, C.]Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, 350001, China
  • [ 19 ] [Chen, C.]Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University350001, China
  • [ 20 ] [Chen, C.]Department of Stem Cell Research Institute, Fujian Medical University, Fuzhou, 350004, China
  • [ 21 ] [Wang, D.]Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, China
  • [ 22 ] [Wang, D.]Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, 350001, China
  • [ 23 ] [Wang, D.]Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University350001, China
  • [ 24 ] [Wang, D.]Department of Stem Cell Research Institute, Fujian Medical University, Fuzhou, 350004, China
  • [ 25 ] [Chen, P.]Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, China
  • [ 26 ] [Chen, P.]Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, 350001, China
  • [ 27 ] [Chen, P.]Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University350001, China
  • [ 28 ] [Chen, P.]Department of Stem Cell Research Institute, Fujian Medical University, Fuzhou, 350004, China
  • [ 29 ] [Tang, S.]Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, China
  • [ 30 ] [Tang, S.]Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, 350001, China
  • [ 31 ] [Tang, S.]Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University350001, China
  • [ 32 ] [Tang, S.]Department of Stem Cell Research Institute, Fujian Medical University, Fuzhou, 350004, China
  • [ 33 ] [Li, J.]Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, China
  • [ 34 ] [Li, J.]Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, 350001, China
  • [ 35 ] [Li, J.]Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University350001, China
  • [ 36 ] [Li, J.]Department of Breast Surgery, Quanzhou First Hospital of Fujian Medical University, Quanzhou, 362000, China
  • [ 37 ] [Qiu, Z.]Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University350001, China
  • [ 38 ] [Qiu, Z.]Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China
  • [ 39 ] [Shi, X.]College of Biological Science and Engineering, Fuzhou University, No. 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 40 ] [Shi, X.]Fujian Key Laboratory of Medical Instrument and Pharmaceutical Technology, Fuzhou University, No. 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 41 ] [Chen, L.]Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University350001, China
  • [ 42 ] [Chen, L.]Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China
  • [ 43 ] [Yang, J.]College of Biological Science and Engineering, Fuzhou University, No. 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 44 ] [Yang, J.]Fujian Key Laboratory of Medical Instrument and Pharmaceutical Technology, Fuzhou University, No. 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 45 ] [Chen, X.]Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, China
  • [ 46 ] [Chen, X.]Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, 350001, China
  • [ 47 ] [Chen, X.]Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University350001, China

Reprint 's Address：

  • [Chen, L.]Engineering Research Center of Tissue and Organ Regeneration, China;;[Yang, J.]College of Biological Science and Engineering, No. 2 Xueyuan Road, China

Email：


chenliangwan@fjmu.edu.cn |
jmyang@fzu.edu.cn
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Source ：

Acta Biomaterialia

ISSN： 1742-7061

Year： 2023

Volume： 159

Page： 111-127

9 . 4

JCR@2023

9 . 4 0 0

JCR@2023

ESI HC Threshold：49

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 26

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

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