Polycyclic　indoles　are　widely　found　in　natural　products　and　pharmaceutical　molecules,　and　have　a　wide　range　of　applications　in　the　pharmaceutical,　pesticide　and　dye　industries.　Although　considerable　development　has　been　made　in　the　synthesis　of　indole　polycycles,　it　is　still　of　great　scientific　interest　and　value　to　explore　more　efficient　and　milder　experimental　strategies　for　the　synthesis　of　highly-functionalized　polycyclic　indoles.　Herein,　a　one-step　radical　tandem　cyclization　reaction　to　synthesize　difluoroalkylindoles　with　quaternary　carbon　centers　by　using　difluorobromoesters　as　the　fluorine　source　and　3-alkenyl　indoles　as　the　substrates　under　visible　light-catalyzed　conditions　was　developed.　The　method　is　easy-to-operate　and　mild　in　conditions,　with　a　wide　range　of　substrate　adaptability　and　good　yields,　providing　a　green　and　efficient　synthetic　route　for　fluorine-containing　polycyclic　indoles.　©　2023　Shanghai　Institute　of　Organic　Chemistry,　Chinese　Academy　of　Sciences.