Light　guide　plate　(LGP)　with　quantum　dots　(QDs)　microstructure　is　commonly　prepared　by　screen　printing,　but　the　morphology　of　microstructure　cannot　be　precisely　controlled.　Inkjet　printing　is　an　emerging　technology　that　allows　accurate　positioning　and　controlled　print　droplet　morphology,　which　can　effectively　solve　this　problem.　However,　studies　on　the　preparation　of　QDs　microstructure　LGP　using　inkjet　printing　are　rare,　and　the　relationship　between　the　morphology　of　inkjet-printed　QDs　microstructure　and　the　performance　of　LGP　is　still　unclear.　Based　on　the　above　hotspots　and　challenges,　this　study　systematically　explores　the　effect　of　inkjet-printed　QDs　microstructure　morphology　on　LGP　performance　by　adjusting　process　parameters　and　combining　with　simulation　models.　Specifically,　the　ideal　radial　length　and　height　ratio　of　the　microstructure　was　firstly　obtained　as　25　by　ray-tracing　simulation　optimization　with　Lighttools.　In　addition,　the　morphology　of　individual　QDs　microstructure　was　optimized　using　the　limiting　effect　of　UV　glue.　Finally,　based　on　the　optimized　process　parameters　and　structure　explored　above,　the　printing　parameters　were　adjusted.　QDs　microstructures　with　regular　distribution,　uniform　size　and　smooth　edges　were　obtained.　The　luminance　uniformity　of　LGP　made　from　them　was　85.35%,　and　it　had　good　current　stability　and　thermal　stability.　It　is　expected　that　these　findings　will　shed　some　new　lights　on　large-scale　application　of　QDs　microstructure　LGP.