The　21st-Century　Maritime　Silk　Road　is　an　important　part　of　the　＂Belt　and　Road　Initiative＂.　It　is　intended　to　carry　out　broader　and　deeper　regional　cooperation　and　to　provide　a　Chinese　solution　for　reforming　the　world　economic　governance　model.　Fujian　Province,　as　the　starting　point　of　the　historical　Maritime　Silk　Road,　its　development　status,　and　the　development　strategy　is　of　vital　importance　for　the　21st-Century　Maritime　Silk　Road＇s　sustainable　and　balanced　regional　development.　Based　on　the　data　on　the　spatial　distribution　of　the　headquarters　and　branches　of　enterprises　in　information-related　industries,　this　study,　from　the　perspective　of　enterprise　connection,　constructed　a　firm　interlocking　network　along　the　south　route　of　the　21st-Century　Maritime　Silk　Road　covering　nodal　cities　along　the　southeast　coast　of　China　and　cities　in　Southeast　Asian　countries.　In　addition,　this　paper　analyzed　the　structural　features　of　the　firm　interlocking　network　in　the　region　from　the　perspectives　of　centrality　and　connectivity　and　considered　the　goal　of　constructing　the　core　area　of　the　21st-Century　Maritime　Silk　Road　to　extract　the　influencing　factors　of　the　firm　interlocking　network.　The　core　factors　influencing　the　centrality　of　cities　were　analyzed　and　identified　by　taking　Fujian　Province　as　an　example.　The　study　found　that　cities　in　Fujian　Province　generally　have　problems　such　as　unremarkable　centrality　and　weak　connectivity　in　the　firm　interlocking　network　in　the　region　and　that　the　three　dimensions　of　policy　coordination,　financial　integration,　and　technology　exchange　in　the　three　cities　of　Fujian　Province　need　to　be　strengthened　despite　the　achievements　made　in　the　three　dimensions　of　facility　connectivity,　unimpeded　trade,　and　closer　people-to-people　bonds.　Policy　suggestions　for　promoting　the　centrality　of　nodal　cities　in　Fujian　Province　and　accelerating　the　integration　into　regional　city　networks　were　made　based　on　the　above　research　findings　and　Fujian　Province＇s　development　goal　of　constructing　a　core　area　of　the　21st-Century　Maritime　Silk　Road.