Knowledge　collaboration　would　not　only　increase　the　teacher　ability,　but　also　enhance　the　competitiveness　of　the　university.　Because　different　knowledge　collaboration　team　has　different　operational　efficiency,　the　paper　analyzes　the　factors　that　influence　the　university　teachers＇　knowledge　collaboration　through　questionnaire　survey.　The　research　is　carried　out　in　three　aspects:　the　collaborative　knowledge,　cooperative　teachers　and　the　collaborative　environment.　It　was　found　that　sharing　tacit　knowledge,　teachers＇　cooperative　ability　and　willingness,　cultural　atmosphere　and　organizational　management　all　affect　the　efficiency　of　knowledge　collaboration.　The　paper　uses　the　＂cause　and　effect　diagram＂　for　summary　so　as　to　take　effective　measures　to　promote　efficiency　of　knowledge　collaboration　timely.