High-cell-density heterotrophic cultivation of microalga Chlorella sorokiniana FZU60 for achieving ultra-high lutein production efficiency - Details

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Abstract：

Chlorella　sorokiniana　has　received　particular　attention　as　a　promising　candidate　for　microalgal　biomass　and　lutein　production.　In　this　work,　heterotrophic　cultivation　was　explored　to　improve　the　lutein　production　efficiency　of　a　lutein-rich　microalga　C.　sorokiniana　FZU60.　Flask　cultivation　results　showed　that　the　highest　lutein　productivity　was　achieved　at　30°C　with　an　initial　cell　concentration　of　1.40　g/L.　Furthermore,　six　types　of　fed-batch　strategies　based　on　nutrient　composition　and　concentration　were　examined　using　a　5　L　fermenter.　Among　them,　ultra-high　lutein　production　(415.93　mg/L)　and　productivity　(82.50　mg/L/d)　with　lutein　content　of　2.57　mg/g　were　achieved　with　fed-batch　3F　(i.e.,　pulse-feeding　with　concentrated　urea-N　medium　to　achieve　a　3-fold　nutrient　concentration).　The　lutein　production　performance　achieved　is　much　higher　than　the　reported　values.　This　work　demonstrates　that　heterotrophic　cultivation　of　C.　sorokiniana　FZU60　with　the　proposed　fed-batch　strategy　could　significantly　enhance　the　production　performance　and　the　commercial　viability　of　microalgae-derived　lutein.　©　2022　Elsevier　Ltd

Keyword：

Chlorella sorokiniana Fed-batch strategy Heterotrophic cultivation Lutein Microalgae

Community：

[ 1 ] [Xie, Y.]Marine Biological Manufacturing Center of Fuzhou Institute of Oceanography, Fuzhou University, Fuzhou, 350108, China
[ 2 ] [Xie, Y.]Fujian Engineering and Technology Research Center for Comprehensive Utilization of Marine Products Waste, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Xie, Y.]Fuzhou Industrial Technology Innovation Center for High Value Utilization of Marine Products, Fuzhou University, Fuzhou, 350108, China
[ 4 ] [Zhang, Z.]Marine Biological Manufacturing Center of Fuzhou Institute of Oceanography, Fuzhou University, Fuzhou, 350108, China
[ 5 ] [Zhang, Z.]Fujian Engineering and Technology Research Center for Comprehensive Utilization of Marine Products Waste, Fuzhou University, Fuzhou, 350108, China
[ 6 ] [Zhang, Z.]Fuzhou Industrial Technology Innovation Center for High Value Utilization of Marine Products, Fuzhou University, Fuzhou, 350108, China
[ 7 ] [Ma, R.]Marine Biological Manufacturing Center of Fuzhou Institute of Oceanography, Fuzhou University, Fuzhou, 350108, China
[ 8 ] [Ma, R.]Fujian Engineering and Technology Research Center for Comprehensive Utilization of Marine Products Waste, Fuzhou University, Fuzhou, 350108, China
[ 9 ] [Ma, R.]Fuzhou Industrial Technology Innovation Center for High Value Utilization of Marine Products, Fuzhou University, Fuzhou, 350108, China
[ 10 ] [Liu, X.]Marine Biological Manufacturing Center of Fuzhou Institute of Oceanography, Fuzhou University, Fuzhou, 350108, China
[ 11 ] [Liu, X.]Fujian Engineering and Technology Research Center for Comprehensive Utilization of Marine Products Waste, Fuzhou University, Fuzhou, 350108, China
[ 12 ] [Liu, X.]Fuzhou Industrial Technology Innovation Center for High Value Utilization of Marine Products, Fuzhou University, Fuzhou, 350108, China
[ 13 ] [Miao, M.]Marine Biological Manufacturing Center of Fuzhou Institute of Oceanography, Fuzhou University, Fuzhou, 350108, China
[ 14 ] [Miao, M.]Fujian Engineering and Technology Research Center for Comprehensive Utilization of Marine Products Waste, Fuzhou University, Fuzhou, 350108, China
[ 15 ] [Miao, M.]Fuzhou Industrial Technology Innovation Center for High Value Utilization of Marine Products, Fuzhou University, Fuzhou, 350108, China
[ 16 ] [Ho, S.-H.]Fujian Engineering and Technology Research Center for Comprehensive Utilization of Marine Products Waste, Fuzhou University, Fuzhou, 350108, China
[ 17 ] [Ho, S.-H.]State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, China
[ 18 ] [Chen, J.]Marine Biological Manufacturing Center of Fuzhou Institute of Oceanography, Fuzhou University, Fuzhou, 350108, China
[ 19 ] [Chen, J.]Fujian Engineering and Technology Research Center for Comprehensive Utilization of Marine Products Waste, Fuzhou University, Fuzhou, 350108, China
[ 20 ] [Chen, J.]Fuzhou Industrial Technology Innovation Center for High Value Utilization of Marine Products, Fuzhou University, Fuzhou, 350108, China
[ 21 ] [Kit Leong, Y.]Department of Chemical and Materials Engineering, Tunghai University, Taichung, Taiwan
[ 22 ] [Kit Leong, Y.]Research Center for Smart Sustainable Circular Economy, Tunghai University, Taichung, Taiwan
[ 23 ] [Chang, J.-S.]Department of Chemical and Materials Engineering, Tunghai University, Taichung, Taiwan
[ 24 ] [Chang, J.-S.]Research Center for Smart Sustainable Circular Economy, Tunghai University, Taichung, Taiwan
[ 25 ] [Chang, J.-S.]Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan
[ 26 ] [Chang, J.-S.]Department of Chemical Engineering and Materials Science, Yuan Ze University, Chung-Li, 32003, Taiwan

Reprint 's Address：

[Chang, J.-S.]Department of Chemical and Materials Engineering, Taiwan

Email：

changjs@thu.edu.tw

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Related Keywords：

High-cell-density heterotrophic cultivation of microalga Chlorella sorokiniana FZU60 for achieving ultra-high lutein production efficiency
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Enhancement of co-production of lutein and protein in Chlorella sorokiniana FZU60 using different bioprocess operation strategies
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Source ：

Bioresource Technology

ISSN： 0960-8524

Year： 2022

Volume： 365

1 1 . 4

JCR@2022

9 . 7 0 0

JCR@2023

ESI HC Threshold：60

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 15

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

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