Photocatalysis　offers　a　sustainable　approach　for　recalcitrant　organic　pollutants　degradation,　yet　it　is　still　challenging　to　seek　robust　photocatalysts　for　application　purposes.　Herein,　a　novel　NiFe　layered　double　hydroxide　(LDH)/covalent　triazine　framework　(CTF-1)　Z-scheme　heterojunction　photocatalyst　was　rationally　designed　for　antibiotics　degradation　under　visible　light　irradiation.　The　NiFe-LDH/CTF-1　nanocomposites　were　readily　obtained　via　in　situ　loading　of　NiFe-LDH　on　CTF-1　through　covalent　linking.　The　abundant　coupling　interfaces　between　two　semiconductor　counterparts　lay　the　foundation　for　the　formation　of　Z-scheme　heterostructure,　thereby　effectively　promoting　the　transfer　of　photogenerated　electrons,　inhibiting　the　recombination　of　carriers,　as　well　as　conferring　the　nanocomposites　with　stronger　redox　ability.　Consequently,　the　optimal　photocatalytic　activity　of　the　LDH/CTF　heterojunction　was　significantly　boosted　for　the　degradation　of　a　typical　antibiotic,　tetracycline　(TC).　Additionally,　the　photodegradation　process　and　the　mineralization　of　TC　were　further　elucidated.　These　results　envision　that　the　LDH/CTF-1　can　be　a　viable　photocatalyst　for　long-term　and　sustainable　wastewater　treatment.　©　2022　by　the　authors.