Nowadays　beta-lactam　antibiotic　is　the　most　valuable　antibiotic,　with　a　crucial　structural　feature　of　a　four-membered　beta-lactam　ring.　The　design　and　synthesis　of　these　compounds,　and　their　stereochemical　characteristics,　have　become　one　of　the　frontier　fields　in　organic　synthesis.　By　virtue　of　its　unique　structure　and　diverse　properties,　ferrocenyl　derivative　has　wide　applications　to　biological　and　medical　fields.　Therefore,　the　ferrocene-modified　beta-lactam　is　a　class　of　compounds　with　a　novel　structure　as　well　as　potentially　biological　activity.　The　in-depth　investigation　of　these　compounds　will　provide　a　significant　guidance　for　the　development　of　new　antibiotics.　Herein　the　research　progress　in　synthesis　and　biological　activity　of　two　types　of　beta-lactam　derivatives　containing　ferrocene　moiety　in　recent　years　is　mainly　summarized,　which　are　ferrocenyl　derivatives　of　penams　and　cephems　and　of　monocyclic　beta-lactams,　respectively.