Online　health-related　misinformation　has　become　a　major　problem　in　society　and　in-depth　research　is　needed　to　understand　its　propagation　patterns　and　underlying　mechanisms.　This　study　proposes　a　psychological　typhoon　eye　effect　to　understand　how　health-related　misinformation　spreads　during　the　pandemic　using　two　national　studies.　In　Study　1,　we　collected　online　search　data　from　the　United　States　and　China　to　explore　the　relationship　between　the　physical　distance　from　the　epicenter　and　the　spread　of　health-related　misinformation.　Two　common　pieces　of　health-related　misinformation　were　examined:　＂Microwaves　kill　coronavirus＂in　the　United　States　and　＂Taking　a　hot　bath　can　prevent　against　COVID-19＂in　China.　Our　results　indicated　a　＂typhoon　eye　effect＂in　the　spread　of　two　actual　pieces　of　health-related　misinformation　using　online　data　from　the　United　States　and　China.　In　Study　2,　we　fabricated　a　piece　of　health-related　misinformation,　＂Wash　Clothes　with　Salt　Water　to　Block　Infection,＂and　measured　the　spread　behavior　and　perceived　credibility　of　the　misinformation.　Again,　we　observed　a　typhoon　eye　effect　on　the　spread　behavior　as　well　as　the　perceived　credibility　of　health-related　misinformation　among　people　with　limited　education.　In　addition,　based　on　the　stimulus-organism-response　theory,　perceived　credibility　could　serve　as　a　mediator　in　the　relationship　between　physical　distance　from　the　epicenter　and　the　spread　of　health-related　misinformation.　Our　results　highlight　the　importance　of　psychological　approaches　to　understanding　the　propagation　patterns　of　health-related　misinformation.　The　present　findings　provide　a　new　perspective　for　development　of　prevention　and　control　strategies　to　reduce　the　spread　of　health-related　misinformation　during　pandemics.　©　2022　Mary　Ann　Liebert,　Inc.,　publishers.