The　traditional　hydrothermal　synthesis　of　molecular　sieve　is　not　environmentally　friendly　in　terms　of　the　synthetic　raw　materials,　because　the　silicon　and　aluminum　reagents　used　in　it　are　prepared　from　natural　aluminosilicate　minerals　through　a　complex　reaction　and　separation　process.　Using　natural　aluminosilicate　minerals　as　silicon　and　aluminum　sources　to　directly　synthesize　molecular　sieve　without　chemical　reagent　intermediates　is　regarded　as　one　of　the　promising　research　directions　for　green　synthesis　of　molecular　sieves.　The　key　is　the　mesoscale　activation　of　natural　aluminosilicate　minerals,　which　refers　to　the　destruction　of　high-polymerization　degree　structure　of　natural　aluminosilicate　minerals　and　the　depolymerization　of　them　into　molecular　sieve　synthetic　raw　materials　with　different　mesoscale　structures　by　means　of　physical,　chemical　or　combination　of　physical　and　chemical　action.　From　the　perspective　of　energy　consumption,　activation　mechanism　and　effect　and　the　mesoscale　structure　of　the　activated　products,　the　research　advances　of　mesoscale　activation　methods　for　natural　minerals　are　summarized　and　the　widely　used　mesoscale　activation　method　such　as　the　mechanical　activation,　thermal　activation,　alkali　fusion　activation,　sub-molten　salt　activation　and　quasi-solid-phase　activation　are　introduced　in　detail.　Based　on　the　development　process　of　mesoscale　activation　methods,　the　present　situations　of　synthesizing　high-performance　molecular　sieves　from　different　mesoscale　activation　products　are　summarized,　which　provides　important　guiding　strategy　for　the　selection　of　mesoscale　activation　methods　aimed　to　the　synthesis　of　high-performance　molecular　sieve.　©　2022　Chemical　Industry　Press.　All　rights　reserved.