Photodynamic　therapy　(PDT),　as　an　alternative　non-invasive　clinical　treatment　modality,　has　been　extensively　employed　for　various　anticancer　applications　in　preclinical　and　clinical　trials.　However,　there　is　hardly　any　PDT　research　based　on　invasive　or　metastatic　tumors.　But　it　can＇t　be　ignored　that　cancer　metastases　are　responsible　for　90%　of　all　cancer-related　death.　Among　these　metastatic　cancers,　prostate　cancer　(PCa)　is　regarded　as　one　of　the　leading　causes　of　cancer　related　deaths　amongst　male　patients　due　to　its　high　metastasis　and　high　fatality　rate.　At　present,　it　remains　a　great　challenge　to　apply　traditional　PDT　technology　for　inhibiting　prostate　cancer　metastasis.　In　this　work,　we　successfully　designed　and　synthesized　a　novel　MAO-A　targeted　photosensitizer　Pc-MLB　for　targeted　photodynamic　treatment　of　prostate　cancer　and　inhibiting　its　metastasis　in　vitro.　In　vitro　experiments　demonstrate　that　Pc-MLB　shows　high　target　affinity　and　specificity　towards　prostate　cancer　cells　and　remarkable　photodynamic　anticancer　activity　compared　with　the　control.　More　significantly,　the　migration　and　invasion　assays　show　that　Pc-MLB　exhibits　the　ability　to　inhibit　the　migration　and　metastasis　of　prostate　cancer　cells　to　some　extent.　©　2022　Elsevier　Ltd