Sour　natural　gas　can　easily　form　clathrate　hydrate　and　cause　the　pipeline　blockage　in　transmission;　salts　and　alcohols　are　usually　added　for　shifting　its　phase　boundary　to　inhibited　regions.　In　this　study,　the　hydrate　equilibrium　conditions　of　two　(CH4+　CO2+　H2S　+　N2)　quaternary　gas　mixtures　(M1and　M2)　in　the　NaCl　solutions　with　and　without　methanol　(MeOH)　are　measured　using　the　isochoric　pressure　searching　method.　The　results　indicated　that　the　hydrate　phase　boundary　of　sour　gas　mixtures　mainly　depended　on　its　composition,　where　the　content　of　H2S　played　a　more　important　role　than　that　of　CO2.　The　presence　of　NaCl　evidently　decreased　the　hydrate　equilibrium　temperature　of　gas　mixtures,　while　the　temperature　suppression　effect　did　not　present　a　linear　relation　to　its　concentration.　Then,　the　20　and　30　wt　%　MeOH　was　added　to　5　wt　%　NaCl　solution,　for　the　CO2-rich　(M1)　and　H2S-rich　(M2)　gas　mixtures;　the　hydrate　suppression　temperatures　reached　12.6　and　17.6　K,　respectively.　The　measured　data　sets　passed　the　thermodynamic　consistency　and　have　good　reliability.　A　thermodynamic　framework　based　on　Chen-Guo　model　and　UNIQUAC　equation　was　proposed　to　predict　the　hydrate　equilibrium　condition　of　sour　gas　and　mixtures　in　the　aqueous　solutions　containing　salts　and　alcohols.　For　the　data　sets　measured　in　this　work,　our　proposed　model　presented　a　smaller　AADP　(%)　(average　absolute　deviation　percent　in　pressure)　than　the　commercial　programs　(PVTsim,　Multiflash,　CSMGem).　For　the　literature　data　sets　(116　points)　on　the　sour　gas　and　mixtures　in　the　presence　of　alcohols　[MeOH　and　ethylene　glycol　(EG)]　and/or　salts　(NaCl,　KCl,　and　CaCl2),　this　study　also　exhibited　a　higher　accuracy　than　previous　works.　©　2022　American　Chemical　Society.　All　rights　reserved.