Photocatalysis　provides　a　green　strategy　to　eliminate　the　emerging　pollutants　of　antibiotics.　However,　it　remains　challenging　to　design　robust　photocatalyst　to　fulfil　the　requirement　of　industrial　implementation.　Herein,　a　novel　Z-scheme　covalent　triazine-based　framework　(CTF)-Bi2WO6　heterojunction　photocatalyst　was　rationally　fabricated　by　interfacial　engineering　of　layered　CTF-1　into　flower-like　Bi2WO6　for　photocatalytic　removal　of　antibiotic,　using　tetracycline　(TC)　as　a　representative.　The　structural,　physicochemical,　and　electrochemical　capabilities　of　the　as-prepared　photocatalyst　were　explored　in　detail　by　a　range　of　advanced　analyses.　The　results　showed　that　the　optimized　CTF-Bi2WO6　exhibited　superior　photocatalytic　performance,　affording　a　TC　removal　efficacy　of　77.14　%　within　60　min,　which　was　approximately　18　times　and　2.67　times　that　of　individual　CTF-1　and　Bi2WO6,　respectively.　The　boosting　property　could　be　attributed　to　the　Z-scheme　heterostructure,　which　significantly　reinforced　the　transfer　and　separation　of　photoinduced　carriers.　Meanwhile,　the　dominate　reactive　species　participating　in　the　degradation　process　were　probed　as　[rad]O2−　and　h+　based　on　scavenger　experiments　and　ESR　analyses.　Finally,　the　degradation　pathway　of　TC　by　CTF-Bi2WO6　was　proposed　based　on　intermediate　products,　and　the　toxicity　of　TC　and　its　degradation　products　were　estimated　by　the　toxicity　estimation　software　tool　(T.E.S.T.).　This　study　showcases　a　feasible　pathway　towards　designing　CTF-based　Z-scheme　heterojunction　photocatalysts　for　effective　and　eco-friendly　antibiotic　wastewater　treatment.　©　2022　Elsevier　Ltd