The　adoption　of　protection　routing　guarantees　the　existence　of　a　loop-free　alternate　path　for　packet　forwarding　when　a　single　link　or　node　failure　occurs.　By　Tapolcai＇s　method,　the　presence　of　two　completely　independent　spanning　trees　(CISTs　for　short)　suffices　to　configure　a　protection　routing.　This　article　extends　the　idea　of　protection　routing　to　involve　more　CISTs　and　attach　a　secure　mechanism　in　the　configuration,　which　we　call　the　secure　multi-protection　routing　scheme　(SMPR-scheme).　Then,　we　use　the　SMPR-scheme　to　deal　with　privacy-preserving　data　transmissions,　such　as　downloading　personal　medical　records,　tax　bills,　or　other　private　information.　To　evaluate　the　effectiveness　of　the　SMPR-scheme,　we　develop　a　probabilistic　model　that　allows　some　malicious　nodes　to　collect　information　illegally　through　neighboring　access.　We　experimented　with　SMPR-scheme　on　the　BCube　(i.e.,　the　generalized　hypercube)　datacenter　network.　Simulation　results　show　that　data　transmission　using　SMPR-scheme　ensures　confidentiality　(i.e.,　no　node　other　than　the　recipient　can　receive　the　complete　message)　and　effectively　resists　privacy　collection　even　under　malicious　infringement.　©　2022　Elsevier　Inc.