ZnO　is　an　important　component　in　skin-protection　products　and　wound-care　medicines.　However,　ZnO＇s　antibacterial　activity　is　moderate.　We　developed　two　types　of　ZnO　microparticles　loading　with　phthalocyanine-type　photosensitizers　(ZnO/PSs)　introducing　the　photodynamic　effects.　These　photosensitive　ZnO　microparticles　exhibited　long-term　while　moderate　antimicrobial　effects　by　continuously　releasing　Zn2+　ions.　The　antimicrobial　efficacies　were　remarkably　enhanced　by　triggering　the　photodynamic　antimicrobial　effects.　Compared　to　the　sole　ZnO　which　showed　non-measurable　antimicrobial　activity　at　a　concentration　of　10　mg/L,　both　ZnO/PSs　demonstrated　antimicrobial　rates　ranged　99%–99.99%　against　Escherichia　coli,　normal　and　drug-resistant　Staphylococcus　aureus.　In　a　dorsal　wound　infection　mouse　model,　treatment　with　ZnO/PSs　significantly　accelerated　the　wound　recovery　rates.　ZnO/PSs　promoted　wound　healing　by　a　dual　effect:　1)　the　release　of　Zn2+　ions　from　ZnO　facilitating　tissue　remodeling;　2)　the　photodynamic　effect　efficiently　eliminates　pathogens　avoiding　infection.　Notably,　ZnO/PSs　inherited　the　high　biosafety　of　ZnO　without　causing　noticeable　toxicity　against　erythrocyte　and　endothelial　cells.　This　study　not　only　provides　a　highly　safe　and　efficient　antimicrobial　ZnO　material　for　skin　cares　and　wound　modulations,　but　also　proposes　a　strategy　to　functionalize　ZnO　materials.　©　2022　Elsevier　B.V.