N6-methyladenosine　(m6A)　abundantly　exists　in　the　cerebral　cortex　and　is　emerging　as　an　essential　factor　in　cortical　development　and　function.　As　the　m6A-binding　site　appears　to　be　dynamically　methylated　in　different　RNA　regions　at　the　temporal-specific　developing　stage,　it　is　of　value　to　distinguish　the　unique　character　of　region-　and　temporal-specific　m6A.　Herein,　we　analyzed　the　status　of　temporal-specific　m6A　within　RNA　5　&　PRIME;　untranslated　region　(5　&　PRIME;UTR)　using　m6A-methylated　sequencing　data　and　transcriptomic　sequencing　data　from　12.5-　to　13-day　embryonic　cerebral　cortices　and　14-day　postnatal　ones.　We　identified　sorts　of　RNAs　that　are　uniquely　m6A-methylated　in　the　5＇UTR　and　sorted　them　into　specific　neurological　processes.　Compared　with　3＇UTR-m6A-methylated　RNAs,　5＇UTR-m6A-methylated　RNAs　showed　unique　functions　and　mechanisms　in　regulating　cortical　development,　especially　through　the　pathway　of　mRNA　transport　and　surveillance.　Moreover,　the　5＇UTR-specific　m6A　was　associated　with　neurological　disorders　as　well.　The　FoxO　signaling　pathway　was　then　focused　by　these　pathogenic　5＇UTR-m6A-methylated　RNAs　and　explored　to　be　involved　in　the　determination　of　neurological　disorders.　Additionally,　the　5＇UTR-m6A　modification　patterns　and　transcriptional　patterns　play　independent　but　cohesive　roles　in　the　developing　cortices.　Our　study　emphasizes　the　importance　of　5＇UTR-specific　m6A　in　the　developing　cortex　and　provides　an　informative　reference　for　future　studies　of　5＇UTR-specific　m6A　in　normal　cortical　development　and　neurological　disorders.　(C)　2021　S.　Karger　AG,　Basel