In　this　study,　three　natural　minerals,　including　rectorite,　bauxite　and　kaolin,　were　used　as　supports　to　prepare　the　Mo-based　catalysts　for　slurry-phase　hydrocracking　by　impregnation　method.　The　compositions　and　structure　of　natural　minerals,　the　reducibility　of　metal　components　on　catalysts,　and　the　relationship　between　catalyst　properties　and　the　product　distribution　were　studied.　Natural　minerals　and　catalysts　were　characterized　by　X-ray　fluorescence　(XRF),　X-ray　diffraction　(XRD),　N2　adsorption-desorption　and　H2　temperature　programmed　reduction　(H2-TPR).　Results　show　that　the　mass　fractions　of　Fe2O3　in　rectorite　and　bauxite　are　8.2%　and　19.1%,　respectively,　obviously　higher　than　that　of　kaolin,　and　higher　amounts　of　easily　reduced　Mo　oxide　and　Fe　oxide　in　the　catalysts　supported　on　rectorite　are　observed　according　to　the　H2-TPR　result.　The　catalyst　supported　on　rectorite　presents　better　performance,　in　which　the　total　yield　of　naphtha　and　middle　distillates　is　50.6%,　significantly　higher　than　that　of　the　catalysts　supported　on　bauxite　and　kaolin.　Meanwhile,　the　corresponding　yield　of　gas　is　lower　than　that　of　other　catalysts.　©　2022,　Editorial　Office　of　Acta　Petrolei　Sinica(Petroleum　Processing　Section).　All　right　reserved.