Abstract:
目的探讨酪氨酸激酶受体1短发夹RNA (Tie1-shRNA)对高糖培养的大鼠内皮细胞(rECs)Tie1的表达的影响。方法将rECs分为对照组、高糖组、高糖+慢病毒组和高糖+Tie1-shRNA组4组。构建Tie1-shRNA慢病毒载体,作用于高糖培养的rECs,干扰酪氨酸激酶受体1 (Tie1)mRNA的表达;采用MTT法检测细胞增殖情况,细胞划痕实验检测细胞迁移情况,Western blot检测rECs中Tie1、血管内皮生长因子-A (VEGF-A)、基质金属蛋白酶-2 (MMP-2)和基质金属蛋白酶-9 (MMP-9)的蛋白表达。结果细胞增殖活性4组间差异有统计学意义(F=48.93...
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福建医药杂志
ISSN: 1002-2600
CN: 35-1071/R
Year: 2021
Issue: 04
Volume: 43
Page: 122-125
Cited Count:
SCOPUS Cited Count:
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 5
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